Literature DB >> 28392482

Adult stem cells in psychiatric disorders - New discoveries in peripheral blood.

Jolanta Kucharska-Mazur1, Marcin Jabłoński1, Błażej Misiak2, Dorota Frydecka3, Janusz Rybakowski4, Mariusz Z Ratajczak5, Jerzy Samochowiec6.   

Abstract

The new area of research in psychiatric disorders is concerned with abnormal regeneration processes. The role of brain neurogenesis has been studied for decades. New discoveries, concerned with the pluripotency of VSEL cells and the role of factors involved in stem cell trafficking in peripheral blood create hope that it will be possible to develop a better understanding of the processes of neuroregeneration/neurodegeneration. There is an ongoing research investigating concentrations of: sphingosine -1-phosphate, SDF-1, elements of complement cascade, and stem cells in peripheral blood, including their possible connection to psychiatric disorders. Collected data, suggesting an abnormal course of regeneration processes in psychiatric disorders, raises hope of finding new potential markers of psychosis and anxiety disorders.
Copyright © 2017 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Anxiety disorder; Bipolar disorder; Complement cascade; Schizophrenia; Sphingosine-1-phosphate; Stem cell; VSEL

Mesh:

Year:  2017        PMID: 28392482     DOI: 10.1016/j.pnpbp.2017.04.005

Source DB:  PubMed          Journal:  Prog Neuropsychopharmacol Biol Psychiatry        ISSN: 0278-5846            Impact factor:   5.067


  5 in total

Review 1.  Stem cells and their potential clinical applications in psychiatric disorders.

Authors:  Mariusz Z Ratajczak; Andrzej K Ciechanowicz; Jolanta Kucharska-Mazur; Jerzy Samochowiec
Journal:  Prog Neuropsychopharmacol Biol Psychiatry       Date:  2017-04-20       Impact factor: 5.067

2.  Stem cells and mechanisms regulating their trafficking - a new and challenging area of investigation in modern psychiatry.

Authors:  Mariusz Z Ratajczak
Journal:  Prog Neuropsychopharmacol Biol Psychiatry       Date:  2018-01-03       Impact factor: 5.067

3.  Assessment of Complement Cascade Components in Patients With Bipolar Disorder.

Authors:  Artur Reginia; Jolanta Kucharska-Mazur; Marcin Jabłoński; Marta Budkowska; Barbara Dołȩgowska; Leszek Sagan; Błazej Misiak; Mariusz Z Ratajczak; Janusz K Rybakowski; Jerzy Samochowiec
Journal:  Front Psychiatry       Date:  2018-11-27       Impact factor: 4.157

Review 4.  ATP-Nlrp3 Inflammasome-Complement Cascade Axis in Sterile Brain Inflammation in Psychiatric Patients and its Impact on Stem Cell Trafficking.

Authors:  Mariusz Z Ratajczak; Aaron Mack; Kamila Bujko; Alison Domingues; Daniel Pedziwiatr; Magda Kucia; Janina Ratajczak; Henning Ulrich; Jolanta Kucharska-Mazur; Jerzy Samochowiec
Journal:  Stem Cell Rev Rep       Date:  2019-08       Impact factor: 5.739

Review 5.  Sterile Inflammation of Brain, due to Activation of Innate Immunity, as a Culprit in Psychiatric Disorders.

Authors:  Mariusz Z Ratajczak; Daniel Pedziwiatr; Monika Cymer; Magda Kucia; Jolanta Kucharska-Mazur; Jerzy Samochowiec
Journal:  Front Psychiatry       Date:  2018-02-28       Impact factor: 4.157

  5 in total

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