Chaoran Ma1, Milena Pavlova1, Yesong Liu1, Ying Liu1, Chunmei Huangfu1, Shouling Wu1, Xiang Gao2. 1. From the Department of Nutritional Sciences (C.M., X.G.), The Pennsylvania State University, University Park; Department of Neurology (M.P.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; and Departments of Neurology (Yesong Liu, Ying Liu, C.H.) and Cardiology (S.W.), Kailuan General Hospital, Tangshan, China. 2. From the Department of Nutritional Sciences (C.M., X.G.), The Pennsylvania State University, University Park; Department of Neurology (M.P.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; and Departments of Neurology (Yesong Liu, Ying Liu, C.H.) and Cardiology (S.W.), Kailuan General Hospital, Tangshan, China. xxg14@psu.edu drwusl@163.com.
Abstract
OBJECTIVE: To examine whether probable REM sleep behavior disorder (pRBD) was associated with increased risk of developing stroke in a community-based cohort. METHODS: The study included 12,003 participants (mean age 54.0 years) of the Kailuan Study, free of stroke, cancer, Parkinson disease, dementia, and head injury at baseline (2012). We determined pRBD using a validated REM sleep behavior disorder (RBD) questionnaire in 2012. Incident stroke cases were confirmed by review of medical records. We used Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of stroke according to pRBD status, adjusting for several sleep measures (i.e., insomnia, daytime sleepiness, sleep duration, snoring, and use of hypnotics) and other potential confounders. RESULTS: During 3 years of follow-up, we documented 159 incident stroke cases. Relative to participants without pRBD at the baseline, those with pRBD had a 157% higher risk (95% CI 59%-313%) of developing stroke. Presence of pRBD was associated with increased risk of both stroke types-the adjusted HR was 1.93 (95% CI 1.07-3.46) for ischemic stroke and 6.61 (95% CI 2.27-19.27) for hemorrhagic stroke. CONCLUSIONS: Presence of pRBD was associated with a higher risk of developing stroke, including both ischemic and hemorrhagic types. Future studies with clinically confirmed RBD and a longer follow-up would be appropriate to further investigate this association.
OBJECTIVE: To examine whether probable REM sleep behavior disorder (pRBD) was associated with increased risk of developing stroke in a community-based cohort. METHODS: The study included 12,003 participants (mean age 54.0 years) of the Kailuan Study, free of stroke, cancer, Parkinson disease, dementia, and head injury at baseline (2012). We determined pRBD using a validated REM sleep behavior disorder (RBD) questionnaire in 2012. Incident stroke cases were confirmed by review of medical records. We used Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of stroke according to pRBD status, adjusting for several sleep measures (i.e., insomnia, daytime sleepiness, sleep duration, snoring, and use of hypnotics) and other potential confounders. RESULTS: During 3 years of follow-up, we documented 159 incident stroke cases. Relative to participants without pRBD at the baseline, those with pRBD had a 157% higher risk (95% CI 59%-313%) of developing stroke. Presence of pRBD was associated with increased risk of both stroke types-the adjusted HR was 1.93 (95% CI 1.07-3.46) for ischemic stroke and 6.61 (95% CI 2.27-19.27) for hemorrhagic stroke. CONCLUSIONS: Presence of pRBD was associated with a higher risk of developing stroke, including both ischemic and hemorrhagic types. Future studies with clinically confirmed RBD and a longer follow-up would be appropriate to further investigate this association.
Authors: Wai Kwong Tang; Dirk M Hermann; Yang Kun Chen; Hua Jun Liang; Xiang Xin Liu; Winnie Chui Wing Chu; Anil T Ahuja; Jill Abrigo; Vincent Mok; Gabor S Ungvari; Ka Sing Wong Journal: BMC Neurol Date: 2014-04-23 Impact factor: 2.474
Authors: Yves Dauvilliers; Carlos H Schenck; Ronald B Postuma; Alex Iranzo; Pierre-Herve Luppi; Giuseppe Plazzi; Jacques Montplaisir; Bradley Boeve Journal: Nat Rev Dis Primers Date: 2018-08-30 Impact factor: 52.329