Literature DB >> 28389578

Exposing HIV's weaknesses.

Philip R Tedbury1,2, Stefan G Sarafianos3,2,4.   

Abstract

The viral restriction factor SERINC5 inhibits HIV-1 infection via unknown mechanisms. Sood and co-workers now show that SERINC5 suppresses HIV-1 fusogenicity and increases sensitivity to neutralizing antibodies by perturbing the folding of the fusion machinery. This work advances our understanding of host-virus interactions and provides a compelling case for considering the host immune system in studies of restriction factor mechanisms.
© 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

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Year:  2017        PMID： 28389578      PMCID： PMC5392592          DOI： 10.1074/jbc.H117.777714

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  10 in total

1.  The Potency of Nef-Mediated SERINC5 Antagonism Correlates with the Prevalence of Primate Lentiviruses in the Wild.

Authors:  Anke Heigele; Dorota Kmiec; Kerstin Regensburger; Simon Langer; Lukas Peiffer; Christina M Stürzel; Daniel Sauter; Martine Peeters; Massimo Pizzato; Gerald H Learn; Beatrice H Hahn; Frank Kirchhoff
Journal:  Cell Host Microbe       Date:  2016-09-14       Impact factor: 21.023

2.  Effect of HIV-1 Env on SERINC5 Antagonism.

Authors:  Saina Beitari; Shilei Ding; Qinghua Pan; Andrés Finzi; Chen Liang
Journal:  J Virol       Date:  2017-01-31       Impact factor: 5.103

3.  SERINC5 protein inhibits HIV-1 fusion pore formation by promoting functional inactivation of envelope glycoproteins.

Authors:  Chetan Sood; Mariana Marin; Ajit Chande; Massimo Pizzato; Gregory B Melikyan
Journal:  J Biol Chem       Date:  2017-02-08       Impact factor: 5.157

4.  Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene.

Authors:  M Y Chowers; C A Spina; T J Kwoh; N J Fitch; D D Richman; J C Guatelli
Journal:  J Virol       Date:  1994-05       Impact factor: 5.103

5.  Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions.

Authors:  James B Munro; Jason Gorman; Xiaochu Ma; Zhou Zhou; James Arthos; Dennis R Burton; Wayne C Koff; Joel R Courter; Amos B Smith; Peter D Kwong; Scott C Blanchard; Walther Mothes
Journal:  Science       Date:  2014-10-08       Impact factor: 47.728

6.  S2 from equine infectious anemia virus is an infectivity factor which counteracts the retroviral inhibitors SERINC5 and SERINC3.

Authors:  Ajit Chande; Emilia Cristiana Cuccurullo; Annachiara Rosa; Serena Ziglio; Susan Carpenter; Massimo Pizzato
Journal:  Proc Natl Acad Sci U S A       Date:  2016-11-01       Impact factor: 11.205

7.  Molecular architecture of native HIV-1 gp120 trimers.

Authors:  Jun Liu; Alberto Bartesaghi; Mario J Borgnia; Guillermo Sapiro; Sriram Subramaniam
Journal:  Nature       Date:  2008-07-30       Impact factor: 49.962

8.  Nef decreases HIV-1 sensitivity to neutralizing antibodies that target the membrane-proximal external region of TMgp41.

Authors:  Rachel P J Lai; Jin Yan; Jonathan Heeney; Myra O McClure; Heinrich Göttlinger; Jeremy Luban; Massimo Pizzato
Journal:  PLoS Pathog       Date:  2011-12-15       Impact factor: 6.823

9.  HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation.

Authors:  Annachiara Rosa; Ajit Chande; Serena Ziglio; Veronica De Sanctis; Roberto Bertorelli; Shih Lin Goh; Sean M McCauley; Anetta Nowosielska; Stylianos E Antonarakis; Jeremy Luban; Federico Andrea Santoni; Massimo Pizzato
Journal:  Nature       Date:  2015-09-30       Impact factor: 49.962

10.  SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef.

Authors:  Yoshiko Usami; Yuanfei Wu; Heinrich G Göttlinger
Journal:  Nature       Date:  2015-09-30       Impact factor: 49.962
  10 in total
  2 in total

Review 1.  SERINC as a Restriction Factor to Inhibit Viral Infectivity and the Interaction with HIV.

Authors:  Gracia Viviana Gonzalez-Enriquez; Martha Escoto-Delgadillo; Eduardo Vazquez-Valls; Blanca Miriam Torres-Mendoza
Journal:  J Immunol Res       Date:  2017-11-22       Impact factor: 4.818

2.  Inhibition of HIV Replication by Apolipoprotein A-I Binding Protein Targeting the Lipid Rafts.

Authors:  Larisa Dubrovsky; Adam Ward; Soo-Ho Choi; Tatiana Pushkarsky; Beda Brichacek; Christophe Vanpouille; Alexei A Adzhubei; Nigora Mukhamedova; Dmitri Sviridov; Leonid Margolis; Richard B Jones; Yury I Miller; Michael Bukrinsky
Journal:  mBio       Date:  2020-01-21       Impact factor: 7.867
  2 in total

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