Yan Epelboym1, Carlos Estrada2, Judy Estroff2. 1. Brigham & Women's Hospital, Boston, MA, USA. Electronic address: YEpelboym@partners.org. 2. Boston Children's Hospital, Boston, MA, USA.
Abstract
OBJECTIVES: The purpose of this study was to assess the positive predictive value of a prenatal ultrasound diagnosis of hypospadias when compared with postnatal diagnosis based on physical exam. METHODS: We retrospectively identified all pregnant women between 2004 and 2014 who were either referred to our fetal care center carrying a fetus with an ultrasound diagnosis of possible hypospadias or who had a new diagnosis of hypospadias after imaging in our center. RESULTS: A total of 32 cases of possible hypospadias were identified, with our fetal center ultrasound suggesting hypospadias in 25 of the 32 cases (78%). Of the 25 cases, 18 infants were confirmed to have hypospadias on postnatal physical exam (Table), reflecting a positive predictive value of 72%. Twenty-one of twenty-five cases with suggested hypospadias on ultrasound were found to have either hypospadias or another penile anomaly on postnatal physical exam, reflecting a positive predictive value for any genital anomaly of 84%. Infants with confirmed hypospadias often had several associated GU anomalies on postnatal clinical exam. CONCLUSIONS: Our single center experience with the fetal ultrasound diagnosis of hypospadias demonstrates a high positive predictive value for a penile anomaly (21/25, 84%), and a moderately high positive predictive value for the specific diagnosis of hypospadias (18/25, 72%) when compared with the postnatal diagnosis.
OBJECTIVES: The purpose of this study was to assess the positive predictive value of a prenatal ultrasound diagnosis of hypospadias when compared with postnatal diagnosis based on physical exam. METHODS: We retrospectively identified all pregnant women between 2004 and 2014 who were either referred to our fetal care center carrying a fetus with an ultrasound diagnosis of possible hypospadias or who had a new diagnosis of hypospadias after imaging in our center. RESULTS: A total of 32 cases of possible hypospadias were identified, with our fetal center ultrasound suggesting hypospadias in 25 of the 32 cases (78%). Of the 25 cases, 18 infants were confirmed to have hypospadias on postnatal physical exam (Table), reflecting a positive predictive value of 72%. Twenty-one of twenty-five cases with suggested hypospadias on ultrasound were found to have either hypospadias or another penile anomaly on postnatal physical exam, reflecting a positive predictive value for any genital anomaly of 84%. Infants with confirmed hypospadias often had several associated GU anomalies on postnatal clinical exam. CONCLUSIONS: Our single center experience with the fetal ultrasound diagnosis of hypospadias demonstrates a high positive predictive value for a penile anomaly (21/25, 84%), and a moderately high positive predictive value for the specific diagnosis of hypospadias (18/25, 72%) when compared with the postnatal diagnosis.