Literature DB >> 28388423

TLRgeting Evasion of Immune Pathways in Glioblastoma.

Gaetano Finocchiaro1.   

Abstract

Glioblastoma (GBM) is an intractable brain cancer that presents a strongly immunosuppressive microenvironment. Alvarado et al. (2016) now report that GBM cancer stem cells (CSCs) downregulate Toll-like receptor (TLR) 4 to evade immune suppression, and that activating downstream TLR signaling pathways can reduce tumor growth and disrupt CSC self-renewal.
Copyright © 2017 Elsevier Inc. All rights reserved.

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Year:  2017        PMID： 28388423     DOI： 10.1016/j.stem.2017.03.018

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   24.633


  9 in total

Review 1.  TLR-4 Signaling vs. Immune Checkpoints, miRNAs Molecules, Cancer Stem Cells, and Wingless-Signaling Interplay in Glioblastoma Multiforme-Future Perspectives.

Authors:  Jakub Litak; Cezary Grochowski; Joanna Litak; Ida Osuchowska; Krzysztof Gosik; Elżbieta Radzikowska; Piotr Kamieniak; Jacek Rolinski
Journal:  Int J Mol Sci       Date:  2020-04-28       Impact factor: 5.923

2.  Pam3CSK4, a TLR2 ligand, induces differentiation of glioblastoma stem cells and confers susceptibility to temozolomide.

Authors:  Javier Megías; Alba Martínez; Teresa San-Miguel; Rosario Gil-Benso; Lisandra Muñoz-Hidalgo; David Albert-Bellver; Amara Carratalá; Daniel Gozalbo; Concha López-Ginés; María Luisa Gil; Miguel Cerdá-Nicolás
Journal:  Invest New Drugs       Date:  2019-05-11       Impact factor: 3.850

3.  Roles of toll-like receptors: From inflammation to lung cancer progression.

Authors:  Jinjing Gu; Yi Liu; Bin Xie; Pingping Ye; Jiefan Huang; Zhe Lu
Journal:  Biomed Rep       Date:  2017-12-28

4.  Discovery of a New CaMKII-Targeted Synthetic Lethal Therapy against Glioblastoma Stem-like Cells.

Authors:  Jang Mi Han; Yu Jin Kim; Hye Jin Jung
Journal:  Cancers (Basel)       Date:  2022-03-04       Impact factor: 6.639

Review 5.  The Glioblastoma Microenvironment: Morphology, Metabolism, and Molecular Signature of Glial Dynamics to Discover Metabolic Rewiring Sequence.

Authors:  Assunta Virtuoso; Roberto Giovannoni; Ciro De Luca; Francesca Gargano; Michele Cerasuolo; Nicola Maggio; Marialuisa Lavitrano; Michele Papa
Journal:  Int J Mol Sci       Date:  2021-03-24       Impact factor: 5.923

6.  Dual Role of WISP1 in maintaining glioma stem cells and tumor-supportive macrophages in glioblastoma.

Authors:  Weiwei Tao; Chengwei Chu; Wenchao Zhou; Zhi Huang; Kui Zhai; Xiaoguang Fang; Qian Huang; Aili Zhang; Xiuxing Wang; Xingjiang Yu; Haidong Huang; Qiulian Wu; Andrew E Sloan; Jennifer S Yu; Xiaoxia Li; George R Stark; Jeremy N Rich; Shideng Bao
Journal:  Nat Commun       Date:  2020-06-15       Impact factor: 14.919

7.  TLR-4/Wnt modulation as new therapeutic strategy in the treatment of glioblastomas.

Authors:  Giovanna Casili; Maria Caffo; Michela Campolo; Valeria Barresi; Gerardo Caruso; Salvatore M Cardali; Marika Lanza; Raffaella Mallamace; Alessia Filippone; Alfredo Conti; Antonino Germanò; Salvatore Cuzzocrea; Emanuela Esposito
Journal:  Oncotarget       Date:  2018-12-25

8.  SATB2 drives glioblastoma growth by recruiting CBP to promote FOXM1 expression in glioma stem cells.

Authors:  Weiwei Tao; Aili Zhang; Kui Zhai; Zhi Huang; Haidong Huang; Wenchao Zhou; Qian Huang; Xiaoguang Fang; Briana C Prager; Xiuxing Wang; Qiulian Wu; Andrew E Sloan; Manmeet S Ahluwalia; Justin D Lathia; Jennifer S Yu; Jeremy N Rich; Shideng Bao
Journal:  EMBO Mol Med       Date:  2020-10-30       Impact factor: 12.137

9.  The novel roles of virus infection-associated gene CDKN1A in chemoresistance and immune infiltration of glioblastoma.

Authors:  Kuan Hu; Juanni Li; Geting Wu; Lei Zhou; Xiang Wang; Yuanliang Yan; Zhijie Xu
Journal:  Aging (Albany NY)       Date:  2021-02-17       Impact factor: 5.682
  9 in total

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