Literature DB >> 2838770

Distribution of mu-opioid receptors in the nucleus raphe magnus and nucleus gigantocellularis: a quantitative autoradiographic study.

R M Bowker1, R P Dilts.   

Abstract

The present study has described and quantitated the distribution of mu-opioid receptors in the nucleus raphe magnus (NRM) and nucleus gigantocellularis (NGC), using in vitro autoradiography. Moderately dense binding of a mu-enkephalin analog, DAGO, was observed in the NRM and adjacent parts of the NGC. DAGO binding density was greatest in the anterior NRM, possibly due to a greater involvement in the descending, opiate-mediated modulation of nociception. These findings agree with proposed roles for this region in the central regulation of pain.

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Year:  1988        PMID： 2838770     DOI： 10.1016/0304-3940(88)90218-2

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  5 in total

1.  Inhibition of neuropathic pain by selective ablation of brainstem medullary cells expressing the mu-opioid receptor.

Authors:  F Porreca; S E Burgess; L R Gardell; T W Vanderah; T P Malan; M H Ossipov; D A Lappi; J Lai
Journal:  J Neurosci       Date:  2001-07-15       Impact factor: 6.167

2.  Activation of serotonergic neurons in the raphe magnus is not necessary for morphine analgesia.

Authors:  K Gao; D O Chen; J R Genzen; P Mason
Journal:  J Neurosci       Date:  1998-03-01       Impact factor: 6.167

3.  mu Opiate receptor immunoreactivity in rat central nervous system.

Authors:  A Moriwaki; J B Wang; A Svingos; E van Bockstaele; P Cheng; V Pickel; G R Uhl
Journal:  Neurochem Res       Date:  1996-11       Impact factor: 3.996

4.  mu-Opioid and delta-opioid receptors are expressed in brainstem antinociceptive circuits: studies using immunocytochemistry and retrograde tract-tracing.

Authors:  A E Kalyuzhny; U Arvidsson; W Wu; M W Wessendorf
Journal:  J Neurosci       Date:  1996-10-15       Impact factor: 6.167

5.  Opioid actions on single nucleus raphe magnus neurons from rat and guinea-pig in vitro.

Authors:  Z Z Pan; J T Williams; P B Osborne
Journal:  J Physiol       Date:  1990-08       Impact factor: 5.182
  5 in total

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