Literature DB >> 2838756

DNA sequence determinants of CAP-induced bending and protein binding affinity.

M R Gartenberg1, D M Crothers.   

Abstract

The sites of DNA bending induced by binding catabolite activator protein are identified and shown to coincide with positions where DNA grooves face the protein. The bendability of DNA with different sequences at these bend centres parallels the bending preference of the sequences in nucleosomal DNA. Anisotropic DNA bendability significantly affects the structure and strength of regulatory protein-DNA complexes.

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Year:  1988        PMID： 2838756     DOI： 10.1038/333824a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  97 in total

1.  SfiI endonuclease activity is strongly influenced by the non-specific sequence in the middle of its recognition site.

Authors:  S A Williams; S E Halford
Journal:  Nucleic Acids Res       Date:  2001-04-01       Impact factor: 16.971

2.  Mechanism for specificity by HMG-1 in enhanceosome assembly.

Authors:  K B Ellwood; Y M Yen; R C Johnson; M Carey
Journal:  Mol Cell Biol       Date:  2000-06       Impact factor: 4.272

3.  High-throughput approach for detection of DNA bending and flexibility based on cyclization.

Authors:  Yongli Zhang; Donald M Crothers
Journal:  Proc Natl Acad Sci U S A       Date:  2003-03-10       Impact factor: 11.205

4.  Structural origins of adenine-tract bending.

Authors:  Andrej Barbic; Daniel P Zimmer; Donald M Crothers
Journal:  Proc Natl Acad Sci U S A       Date:  2003-02-13       Impact factor: 11.205

5.  Protein-induced bending and DNA cyclization.

Authors:  J D Kahn; D M Crothers
Journal:  Proc Natl Acad Sci U S A       Date:  1992-07-15       Impact factor: 11.205

6.  Predicting indirect readout effects in protein-DNA interactions.

Authors:  Yongli Zhang; Zhiqun Xi; Rashmi S Hegde; Zippora Shakked; Donald M Crothers
Journal:  Proc Natl Acad Sci U S A       Date:  2004-05-17       Impact factor: 11.205

Review 7.  Catabolite activator protein: DNA binding and transcription activation.

Authors:  Catherine L Lawson; David Swigon; Katsuhiko S Murakami; Seth A Darst; Helen M Berman; Richard H Ebright
Journal:  Curr Opin Struct Biol       Date:  2004-02       Impact factor: 6.809

8.  Functional specificity of a protein-DNA complex mediated by two arginines bound to the minor groove.

Authors:  Jesús Mendieta; Laura Pérez-Lago; Margarita Salas; Ana Camacho
Journal:  J Bacteriol       Date:  2012-06-29       Impact factor: 3.490

9.  Helical repeat and chirality effects on DNA gel electrophoretic mobility.

Authors:  J Drak; D M Crothers
Journal:  Proc Natl Acad Sci U S A       Date:  1991-04-15       Impact factor: 11.205

10.  Consensus DNA site for the Escherichia coli catabolite gene activator protein (CAP): CAP exhibits a 450-fold higher affinity for the consensus DNA site than for the E. coli lac DNA site.

Authors:  R H Ebright; Y W Ebright; A Gunasekera
Journal:  Nucleic Acids Res       Date:  1989-12-25       Impact factor: 16.971
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