Literature DB >> 28386677

Medulloblastoma: Molecular Classification-Based Personal Therapeutics.

Tenley C Archer1,2, Elizabeth L Mahoney1, Scott L Pomeroy3,4.   

Abstract

Recent advances in cancer genomics have revealed 4 distinct subgroups of medulloblastomas, each with unique transcription profiles, DNA alterations and clinical outcome. Molecular classification of medulloblastomas improves predictions of clinical outcome, allowing more accurate matching of intensity of conventional treatments with chemotherapy and radiation to overall prognosis and setting the stage for the introduction of targeted therapies.

Entities:  

Keywords:  DNA methylation; Genomic; Group 3; Group 4; MYC; Medulloblastoma; SHH; Subgroups; WHO; WNT

Mesh：

Substances：

Year:  2017        PMID： 28386677      PMCID： PMC5398996          DOI： 10.1007/s13311-017-0526-y

Source DB:  PubMed          Journal:  Neurotherapeutics        ISSN： 1878-7479            Impact factor:   7.620


  110 in total

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2.  Multi-institution prospective trial of reduced-dose craniospinal irradiation (23.4 Gy) followed by conformal posterior fossa (36 Gy) and primary site irradiation (55.8 Gy) and dose-intensive chemotherapy for average-risk medulloblastoma.

Authors:  Thomas E Merchant; Larry E Kun; Matthew J Krasin; Dana Wallace; Murali M Chintagumpala; Shiao Y Woo; David M Ashley; Maree Sexton; Stewart J Kellie; Verity Ahern; Amar Gajjar
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3.  UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development.

Authors:  Karl Agger; Paul A C Cloos; Jesper Christensen; Diego Pasini; Simon Rose; Juri Rappsilber; Irina Issaeva; Eli Canaani; Anna Elisabetta Salcini; Kristian Helin
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4.  Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing.

Authors:  Volker Hovestadt; David T W Jones; Simone Picelli; Wei Wang; Marcel Kool; Paul A Northcott; Marc Sultan; Katharina Stachurski; Marina Ryzhova; Hans-Jörg Warnatz; Meryem Ralser; Sonja Brun; Jens Bunt; Natalie Jäger; Kortine Kleinheinz; Serap Erkek; Ursula D Weber; Cynthia C Bartholomae; Christof von Kalle; Chris Lawerenz; Jürgen Eils; Jan Koster; Rogier Versteeg; Till Milde; Olaf Witt; Sabine Schmidt; Stephan Wolf; Torsten Pietsch; Stefan Rutkowski; Wolfram Scheurlen; Michael D Taylor; Benedikt Brors; Jörg Felsberg; Guido Reifenberger; Arndt Borkhardt; Hans Lehrach; Robert J Wechsler-Reya; Roland Eils; Marie-Laure Yaspo; Pablo Landgraf; Andrey Korshunov; Marc Zapatka; Bernhard Radlwimmer; Stefan M Pfister; Peter Lichter
Journal:  Nature       Date:  2014-05-18       Impact factor: 49.962

5.  Medulloblastoma subgroups remain stable across primary and metastatic compartments.

Authors:  Xin Wang; Adrian M Dubuc; Vijay Ramaswamy; Stephen Mack; Deena M A Gendoo; Marc Remke; Xiaochong Wu; Livia Garzia; Betty Luu; Florence Cavalli; John Peacock; Borja López; Patryk Skowron; David Zagzag; David Lyden; Caitlin Hoffman; Yoon-Jae Cho; Charles Eberhart; Tobey MacDonald; Xiao-Nan Li; Timothy Van Meter; Paul A Northcott; Benjamin Haibe-Kains; Cynthia Hawkins; James T Rutka; Eric Bouffet; Stefan M Pfister; Andrey Korshunov; Michael D Taylor
Journal:  Acta Neuropathol       Date:  2015-01-21       Impact factor: 17.088

6.  Defining the molecular landscape of ependymomas.

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Journal:  Cancer Cell       Date:  2015-05-11       Impact factor: 31.743

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Authors:  Ramin Nazarian; Hubing Shi; Qi Wang; Xiangju Kong; Richard C Koya; Hane Lee; Zugen Chen; Mi-Kyung Lee; Narsis Attar; Hooman Sazegar; Thinle Chodon; Stanley F Nelson; Grant McArthur; Jeffrey A Sosman; Antoni Ribas; Roger S Lo
Journal:  Nature       Date:  2010-11-24       Impact factor: 49.962

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10.  Mutational heterogeneity in cancer and the search for new cancer-associated genes.

Authors:  Michael S Lawrence; Petar Stojanov; Paz Polak; Gregory V Kryukov; Kristian Cibulskis; Andrey Sivachenko; Scott L Carter; Chip Stewart; Craig H Mermel; Steven A Roberts; Adam Kiezun; Peter S Hammerman; Aaron McKenna; Yotam Drier; Lihua Zou; Alex H Ramos; Trevor J Pugh; Nicolas Stransky; Elena Helman; Jaegil Kim; Carrie Sougnez; Lauren Ambrogio; Elizabeth Nickerson; Erica Shefler; Maria L Cortés; Daniel Auclair; Gordon Saksena; Douglas Voet; Michael Noble; Daniel DiCara; Pei Lin; Lee Lichtenstein; David I Heiman; Timothy Fennell; Marcin Imielinski; Bryan Hernandez; Eran Hodis; Sylvan Baca; Austin M Dulak; Jens Lohr; Dan-Avi Landau; Catherine J Wu; Jorge Melendez-Zajgla; Alfredo Hidalgo-Miranda; Amnon Koren; Steven A McCarroll; Jaume Mora; Brian Crompton; Robert Onofrio; Melissa Parkin; Wendy Winckler; Kristin Ardlie; Stacey B Gabriel; Charles W M Roberts; Jaclyn A Biegel; Kimberly Stegmaier; Adam J Bass; Levi A Garraway; Matthew Meyerson; Todd R Golub; Dmitry A Gordenin; Shamil Sunyaev; Eric S Lander; Gad Getz
Journal:  Nature       Date:  2013-06-16       Impact factor: 49.962
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  28 in total

1.  Partnership for defining the impact of 12 selected rare CNS tumors: a report from the CBTRUS and the NCI-CONNECT.

Authors:  Gabrielle Truitt; Haley Gittleman; Rebecca Leece; Quinn T Ostrom; Carol Kruchko; Terri S Armstrong; Mark R Gilbert; Jill S Barnholtz-Sloan
Journal:  J Neurooncol       Date:  2019-06-17       Impact factor: 4.130

2.  Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse.

Authors:  Liguo Zhang; Xuelian He; Xuezhao Liu; Feng Zhang; L Frank Huang; Andrew S Potter; Lingli Xu; Wenhao Zhou; Tao Zheng; Zaili Luo; Kalen P Berry; Allison Pribnow; Stephanie M Smith; Christine Fuller; Blaise V Jones; Maryam Fouladi; Rachid Drissi; Zeng-Jie Yang; W Clay Gustafson; Marc Remke; Scott L Pomeroy; Emily J Girard; James M Olson; A Sorana Morrissy; Maria C Vladoiu; Jiao Zhang; Weidong Tian; Mei Xin; Michael D Taylor; S Steven Potter; Martine F Roussel; William A Weiss; Q Richard Lu
Journal:  Cancer Cell       Date:  2019-08-29       Impact factor: 31.743

3.  MR Imaging-Based Radiomic Signatures of Distinct Molecular Subgroups of Medulloblastoma.

Authors:  M Iv; M Zhou; K Shpanskaya; S Perreault; Z Wang; E Tranvinh; B Lanzman; S Vajapeyam; N A Vitanza; P G Fisher; Y J Cho; S Laughlin; V Ramaswamy; M D Taylor; S H Cheshier; G A Grant; T Young Poussaint; O Gevaert; K W Yeom
Journal:  AJNR Am J Neuroradiol       Date:  2018-12-06       Impact factor: 3.825

4.  Medulloblastoma malignant biological behaviors are associated with HOTAIR/miR-483-3p/CDK4 axis.

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5.  Effects of different molecular subtypes and tumor biology on the prognosis of medulloblastoma.

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6.  Mice Expressing Myc in Neural Precursors Develop Choroid Plexus and Ciliary Body Tumors.

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Review 7.  Long-term Survivors of Childhood Brain Tumors: Impact on General Health and Quality of Life.

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Review 8.  Advances in the classification of pediatric brain tumors through DNA methylation profiling: From research tool to frontline diagnostic.

Authors:  Rahul Kumar; Anthony P Y Liu; Brent A Orr; Paul A Northcott; Giles W Robinson
Journal:  Cancer       Date:  2018-09-26       Impact factor: 6.860

9.  Proteomics, Post-translational Modifications, and Integrative Analyses Reveal Molecular Heterogeneity within Medulloblastoma Subgroups.

Authors:  Tenley C Archer; Tobias Ehrenberger; Filip Mundt; Maxwell P Gold; Karsten Krug; Clarence K Mah; Elizabeth L Mahoney; Colin J Daniel; Alexander LeNail; Divya Ramamoorthy; Philipp Mertins; D R Mani; Hailei Zhang; Michael A Gillette; Karl Clauser; Michael Noble; Lauren C Tang; Jessica Pierre-François; Jacob Silterra; James Jensen; Pablo Tamayo; Andrey Korshunov; Stefan M Pfister; Marcel Kool; Paul A Northcott; Rosalie C Sears; Jonathan O Lipton; Steven A Carr; Jill P Mesirov; Scott L Pomeroy; Ernest Fraenkel
Journal:  Cancer Cell       Date:  2018-09-10       Impact factor: 31.743

Review 10.  Factors influencing risk-based care of the childhood cancer survivor in the 21st century.

Authors:  Stephanie B Dixon; Kari L Bjornard; Nicole M Alberts; Gregory T Armstrong; Tara M Brinkman; Wassim Chemaitilly; Matthew J Ehrhardt; Israel Fernandez-Pineda; Lisa M Force; Todd M Gibson; Daniel M Green; Carrie R Howell; Sue C Kaste; Anne C Kirchhoff; James L Klosky; Kevin R Krull; John T Lucas; Daniel A Mulrooney; Kirsten K Ness; Carmen L Wilson; Yutaka Yasui; Leslie L Robison; Melissa M Hudson
Journal:  CA Cancer J Clin       Date:  2018-01-29       Impact factor: 508.702
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