Literature DB >> 28386634

Insights and Lessons from a Scientific Conference on Non-Invasive Delivery of Macromolecules.

Ronak Savla1, Randall J Mrsny2, Kinam Park3, Isabelle Aubert4, Cornell Stamoran5.   

Abstract

A growing share of the pharmaceutical development pipeline is occupied by macromolecule drugs, which are primarily administered by injection. Despite decades of attempts, non-invasive delivery of macromolecules has seen only a few success stories. Potential benefits of non-invasive administration include better patient acceptance and adherence and potentially better efficacy and safety. Greater inter-disciplinary dialogue and collaboration are integral to realizing these benefits.

Entities:  

Keywords:  blood-brain barrier; drug delivery; in vitro models; macromolecules; permeation enhancers

Mesh：

Substances：

Year:  2017        PMID： 28386634     DOI： 10.1007/s11095-017-2156-9

Source DB:  PubMed          Journal:  Pharm Res        ISSN： 0724-8741            Impact factor:   4.200


  4 in total

Review 1.  Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings.

Authors:  C A Lipinski; F Lombardo; B W Dominy; P J Feeney
Journal:  Adv Drug Deliv Rev       Date:  2001-03-01       Impact factor: 15.470

Review 2.  Challenges for the oral delivery of macromolecules.

Authors:  Michael Goldberg; Isabel Gomez-Orellana
Journal:  Nat Rev Drug Discov       Date:  2003-04       Impact factor: 84.694

3.  The developability classification system: application of biopharmaceutics concepts to formulation development.

Authors:  James M Butler; Jennifer B Dressman
Journal:  J Pharm Sci       Date:  2010-12       Impact factor: 3.534

Review 4.  Oral delivery of macromolecular drugs: Where we are after almost 100years of attempts.

Authors:  Elena Moroz; Simon Matoori; Jean-Christophe Leroux
Journal:  Adv Drug Deliv Rev       Date:  2016-01-27       Impact factor: 15.470
  4 in total

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