Literature DB >> 28386521

MicroRNAs as Biomarkers for Psychiatric Conditions: A Review of Current Research.

Anoop Narahari1, Mariyah Hussain1, Venkatesh Sreeram1.   

Abstract

Neural-derived exosomes can be used as diagnostic markers to screen for various psychiatric conditions. These intravenously injected exosomes carry the potential to cross the blood brain barrier and deliver miRNA molecules specifically to neurons, microglia, and oligodendrocytes in the brain, resulting in specific gene knockdown. Here the authors review and discuss the current research on microRNA molecules and the therapeutic roles they may potentially play in treating depression, bipolar disorder, and schizophrenia.

Entities:  

Keywords:  MicroRNA (miR/miRNA); bipolar disorder; depression; hippocampus; messengerRNA (mRNA); neurogenesis; neuronal plasticity; schizophrenia

Year:  2017        PMID： 28386521      PMCID： PMC5373795     

Source DB:  PubMed          Journal:  Innov Clin Neurosci        ISSN： 2158-8333


  15 in total

1.  Asymmetry in the assembly of the RNAi enzyme complex.

Authors:  Dianne S Schwarz; György Hutvágner; Tingting Du; Zuoshang Xu; Neil Aronin; Phillip D Zamore
Journal:  Cell       Date:  2003-10-17       Impact factor: 41.582

2.  Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs.

Authors:  Rui Yi; Yi Qin; Ian G Macara; Bryan R Cullen
Journal:  Genes Dev       Date:  2003-12-17       Impact factor: 11.361

Review 3.  Circadian rhythms and clock genes in psychotic disorders.

Authors:  Elaine Waddington Lamont; Daniel L Coutu; Nicolas Cermakian; Diane B Boivin
Journal:  Isr J Psychiatry Relat Sci       Date:  2010       Impact factor: 0.481

4.  MicroRNA-134 plasma levels before and after treatment for bipolar mania.

Authors:  Han Rong; Tie Bang Liu; Kong Jun Yang; Hai Chen Yang; Dong Hui Wu; Chun Pin Liao; Fei Hong; He Zen Yang; Feng Wan; Xiao Ying Ye; Dan Xu; Xuan Zhang; Chang An Chao; Qi Jie Shen
Journal:  J Psychiatr Res       Date:  2010-05-23       Impact factor: 4.791

5.  Deficiency of Dgcr8, a gene disrupted by the 22q11.2 microdeletion, results in altered short-term plasticity in the prefrontal cortex.

Authors:  Karine Fénelon; Jun Mukai; Bin Xu; Pei-Ken Hsu; Liam J Drew; Maria Karayiorgou; Gerald D Fischbach; Amy B Macdermott; Joseph A Gogos
Journal:  Proc Natl Acad Sci U S A       Date:  2011-02-28       Impact factor: 11.205

6.  The nuclear RNase III Drosha initiates microRNA processing.

Authors:  Yoontae Lee; Chiyoung Ahn; Jinju Han; Hyounjeong Choi; Jaekwang Kim; Jeongbin Yim; Junho Lee; Patrick Provost; Olof Rådmark; Sunyoung Kim; V Narry Kim
Journal:  Nature       Date:  2003-09-25       Impact factor: 49.962

Review 7.  Chromosome 8p as a potential hub for developmental neuropsychiatric disorders: implications for schizophrenia, autism and cancer.

Authors:  R Tabarés-Seisdedos; J L R Rubenstein
Journal:  Mol Psychiatry       Date:  2009-02-10       Impact factor: 15.992

8.  microRNA modulation of circadian-clock period and entrainment.

Authors:  Hai-Ying M Cheng; Joseph W Papp; Olga Varlamova; Heather Dziema; Brandon Russell; John P Curfman; Takanobu Nakazawa; Kimiko Shimizu; Hitoshi Okamura; Soren Impey; Karl Obrietan
Journal:  Neuron       Date:  2007-06-07       Impact factor: 17.173

9.  MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction.

Authors:  Jannet Kocerha; Mohammad Ali Faghihi; Miguel A Lopez-Toledano; Jia Huang; Amy J Ramsey; Marc G Caron; Nicole Sales; David Willoughby; Joacim Elmen; Henrik F Hansen; Henrik Orum; Sakari Kauppinen; Paul J Kenny; Claes Wahlestedt
Journal:  Proc Natl Acad Sci U S A       Date:  2009-02-05       Impact factor: 11.205

Review 10.  The role of circadian clock genes in mental disorders.

Authors:  Elaine Waddington Lamont; Daniel Legault-Coutu; Nicolas Cermakian; Diane B Boivin
Journal:  Dialogues Clin Neurosci       Date:  2007       Impact factor: 5.986
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  10 in total

1.  A miRNA Signature for Cognitive Deficits and Alcohol Use Disorder in Persons Living with HIV/AIDS.

Authors:  Dorota Wyczechowska; Hui-Yi Lin; Andrea LaPlante; Duane Jeansonne; Adam Lassak; Christopher H Parsons; Patricia E Molina; Francesca Peruzzi
Journal:  Front Mol Neurosci       Date:  2017-11-15       Impact factor: 5.639

Review 2.  Exploiting Circulating MicroRNAs as Biomarkers in Psychiatric Disorders.

Authors:  Bhaskar Roy; Yuta Yoshino; Lauren Allen; Kevin Prall; Grant Schell; Yogesh Dwivedi
Journal:  Mol Diagn Ther       Date:  2020-06       Impact factor: 4.074

3.  hsa_circ_0000218/hsa-miR-139-3p/SOX4 regulatory feedback circuit influences the proliferation and apoptosis of gastric cancer cells.

Authors:  Ganlin Xia; Anxin Wang; Liangxue Li
Journal:  Cytotechnology       Date:  2022-01-10       Impact factor: 2.058

Review 4.  Recent advancements in biomarker research in schizophrenia: mapping the road from bench to bedside.

Authors:  Shivangi Patel; Dilip Sharma; Ankit Uniyal; Anagha Gadepalli; Vinod Tiwari
Journal:  Metab Brain Dis       Date:  2022-03-03       Impact factor: 3.655

Review 5.  The emerging role of exosomes in mental disorders.

Authors:  Saumeh Saeedi; Sonia Israel; Corina Nagy; Gustavo Turecki
Journal:  Transl Psychiatry       Date:  2019-03-28       Impact factor: 6.222

6.  Circulating hsa-let-7e-5p and hsa-miR-125a-5p as Possible Biomarkers in the Diagnosis of Major Depression and Bipolar Disorders.

Authors:  Dovydas Gecys; Kristina Dambrauskiene; Sandrita Simonyte; Vaiva Patamsyte; Alvita Vilkeviciute; Algirdas Musneckis; Kristina Butkute-Sliuoziene; Vaiva Lesauskaite; Lukas Zemaitis; Deimante Usaite; Virginija Adomaitiene
Journal:  Dis Markers       Date:  2022-02-07       Impact factor: 3.434

7.  Histone methyltransferase enhancer of zeste 2 polycomb repressive complex 2 subunit exacerbates inflammation in depression rats by modulating microglia polarization.

Authors:  Xuezhu Huang; Qin Yang; Lingling Xie; Sihong Lei
Journal:  Bioengineered       Date:  2022-03       Impact factor: 3.269

8.  Extracellular vesicles are increased in the serum of children with autism spectrum disorder, contain mitochondrial DNA, and stimulate human microglia to secrete IL-1β.

Authors:  Irene Tsilioni; Theoharis C Theoharides
Journal:  J Neuroinflammation       Date:  2018-08-27       Impact factor: 8.322

9.  Extracellular Vesicles in Psychiatry Research in the Context of RDoC Criteria.

Authors:  Can Ilgın; Ahmet Topuzoğlu
Journal:  Psychiatry Investig       Date:  2018-11-02       Impact factor: 2.505

10.  Aging and aging-associated diseases: a microRNA-based endocrine regulation hypothesis.

Authors:  Samuil Umansky
Journal:  Aging (Albany NY)       Date:  2018-10-29       Impact factor: 5.682
  10 in total

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