Kamal Dua1, Venkata Ramana Malipeddi2, Jyotsna Madan3, Gaurav Gupta4, Srikumar Chakravarthi5, Rajendra Awasthi6, Irene Satiko Kikuchi7, Terezinha De Jesus Andreoli Pinto7. 1. School of Pharmacy and Biomedical Sciences, The University of Newcastle , Newcastle, Callaghan, Australia. 2. Amity Institute of Pharmacy, Amity University Uttar Pradesh , Lucknow, India. 3. Department of Pharmaceutics, Sinhgad Technical Education Society, Smt. Kashibai Navale College of Pharmacy , Pune, Maharashtra, India. 4. School of Medicine, The University of Newcastle , Newcastle, Callaghan, Australia. 5. Department of Pathology, Perdana University , Serdang, Selangor, Malaysia. 6. Laureate Institute of Pharmacy , Kangra, Himachal Pradesh, India. 7. Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo , São Paulo, Brazil.
Abstract
INTRODUCTION: Our various previous findings have shown the suitability of norfloxacin in the treatment of bacterial infections and burn wounds in alone as well as in combination with Curcuma longa in various topical (ointments, gels, and creams) and transdermal drug delivery systems. AIMS AND METHODS: Keeping these facts in consideration, we have made an another attempt to prepare semisolid formulations containing 1% w/w of norfloxacin and metronidazole with different bases like Carbopol, polyethylene glycol, and hydroxypropylmethyl cellulose for effective treatment of bacterial infections and burn wounds. The prepared formulations were evaluated for physicochemical parameters, in vitro drug release, antimicrobial activity, and burn wound healing properties. RESULTS: The prepared formulations were compared with Silver Sulfadiazine cream 1%, USP. Antimicrobial activity of norfloxacin semisolid formulations was found to be equally effective against both aerobic and anaerobic bacteria in comparison to a marketed formulation of Silver Sulfadiazine 1% cream, USP. Based on the burn wound healing property, the prepared norfloxacin semisolid formulation was found to be in good agreement with marketed Silver Sulfadiazine 1% cream, USP. CONCLUSIONS: These findings suggest formulations containing norfloxacin and metronidazole may also prove as an effective alternative for existing remedies in the treatment of bacterial infections and burn wounds.
INTRODUCTION: Our various previous findings have shown the suitability of norfloxacin in the treatment of bacterial infections and burn wounds in alone as well as in combination with Curcuma longa in various topical (ointments, gels, and creams) and transdermal drug delivery systems. AIMS AND METHODS: Keeping these facts in consideration, we have made an another attempt to prepare semisolid formulations containing 1% w/w of norfloxacin and metronidazole with different bases like Carbopol, polyethylene glycol, and hydroxypropylmethyl cellulose for effective treatment of bacterial infections and burn wounds. The prepared formulations were evaluated for physicochemical parameters, in vitro drug release, antimicrobial activity, and burn wound healing properties. RESULTS: The prepared formulations were compared with Silver Sulfadiazine cream 1%, USP. Antimicrobial activity of norfloxacin semisolid formulations was found to be equally effective against both aerobic and anaerobic bacteria in comparison to a marketed formulation of Silver Sulfadiazine 1% cream, USP. Based on the burn wound healing property, the prepared norfloxacin semisolid formulation was found to be in good agreement with marketed Silver Sulfadiazine 1% cream, USP. CONCLUSIONS: These findings suggest formulations containing norfloxacin and metronidazole may also prove as an effective alternative for existing remedies in the treatment of bacterial infections and burn wounds.
Authors: Libero I Giannola; Viviana de Caro; Giulia Giandalia; Maria G Siragusa; Lorenzo Cordone Journal: J Ocul Pharmacol Ther Date: 2008-04 Impact factor: 2.671
Authors: María Florencia Sanchez; Susana Andrea Breda; Elio Andrés Soria; Luis Ignacio Tártara; Rubén Hilario Manzo; María Eugenia Olivera Journal: Drug Deliv Transl Res Date: 2018-10 Impact factor: 4.617
Authors: Venkata Ramana Malipeddi; Rajendra Awasthi; Daniela Dal Molim Ghisleni; Marina de Souza Braga; Irene Satiko Kikuchi; Terezinha de Jesus Andreoli Pinto; Kamal Dua Journal: Drug Deliv Transl Res Date: 2017-02 Impact factor: 4.617