Literature DB >> 28385459

Wip1: A candidate phosphatase for cancer diagnosis and treatment.

Tayebeh Oghabi Bakhshaiesh1, Keivan Majidzadeh-A1, Rezvan Esmaeili2.   

Abstract

The critical regulatory mechanisms in numerous cellular pathways including cell survival and DNA damage response mostly depend on phosphorylation and dephosphorylation of proteins. The serine/threonine phosphatase wild-type p53-induced phosphatase 1 (Wip1) is a growth-promoting phosphatase and its numerous downstream targets are important tumor suppressors. Here, we review the Wip1 activity and its relevance to cancer as an oncoprotein. Consecutive investigations about Wip1 and its relation to cancer is critical, as these studies ultimately contribute to the etiology of cancer. A number of innovative studies have recently investigated the importance of Wip1 as a new candidate for cancer diagnosis and prognosis. Accordingly, we discuss the present challenges of using Wip1 as a target for cancer treatment.
Copyright © 2017 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Cancer therapy; DNA damage response; PPM1D; Wip1; p53

Mesh：

Substances：

Year:  2017        PMID： 28385459     DOI： 10.1016/j.dnarep.2017.03.004

Source DB:  PubMed          Journal:  DNA Repair (Amst)        ISSN： 1568-7856


  9 in total

1.  DUSP3 maintains genomic stability and cell proliferation by modulating NER pathway and cell cycle regulatory proteins.

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Journal:  Cell Cycle       Date:  2020-05-07       Impact factor: 4.534

2.  A Four-gene Decision Tree Signature Classification of Triple-negative Breast Cancer: Implications for Targeted Therapeutics.

Authors:  Jelmar Quist; Hasan Mirza; Maggie C U Cheang; Melinda L Telli; Joyce A O'Shaughnessy; Christopher J Lord; Andrew N J Tutt; Anita Grigoriadis
Journal:  Mol Cancer Ther       Date:  2018-10-10       Impact factor: 6.261

3.  The transcriptional landscape of Shh medulloblastoma.

Authors:  Patryk Skowron; Hamza Farooq; Florence M G Cavalli; A Sorana Morrissy; Michelle Ly; Liam D Hendrikse; Evan Y Wang; Haig Djambazian; Helen Zhu; Karen L Mungall; Quang M Trinh; Tina Zheng; Shizhong Dai; Ana S Guerreiro Stucklin; Maria C Vladoiu; Vernon Fong; Borja L Holgado; Carolina Nor; Xiaochong Wu; Diala Abd-Rabbo; Pierre Bérubé; Yu Chang Wang; Betty Luu; Raul A Suarez; Avesta Rastan; Aaron H Gillmor; John J Y Lee; Xiao Yun Zhang; Craig Daniels; Peter Dirks; David Malkin; Eric Bouffet; Uri Tabori; James Loukides; François P Doz; Franck Bourdeaut; Olivier O Delattre; Julien Masliah-Planchon; Olivier Ayrault; Seung-Ki Kim; David Meyronet; Wieslawa A Grajkowska; Carlos G Carlotti; Carmen de Torres; Jaume Mora; Charles G Eberhart; Erwin G Van Meir; Toshihiro Kumabe; Pim J French; Johan M Kros; Nada Jabado; Boleslaw Lach; Ian F Pollack; Ronald L Hamilton; Amulya A Nageswara Rao; Caterina Giannini; James M Olson; László Bognár; Almos Klekner; Karel Zitterbart; Joanna J Phillips; Reid C Thompson; Michael K Cooper; Joshua B Rubin; Linda M Liau; Miklós Garami; Peter Hauser; Kay Ka Wai Li; Ho-Keung Ng; Wai Sang Poon; G Yancey Gillespie; Jennifer A Chan; Shin Jung; Roger E McLendon; Eric M Thompson; David Zagzag; Rajeev Vibhakar; Young Shin Ra; Maria Luisa Garre; Ulrich Schüller; Tomoko Shofuda; Claudia C Faria; Enrique López-Aguilar; Gelareh Zadeh; Chi-Chung Hui; Vijay Ramaswamy; Swneke D Bailey; Steven J Jones; Andrew J Mungall; Richard A Moore; John A Calarco; Lincoln D Stein; Gary D Bader; Jüri Reimand; Jiannis Ragoussis; William A Weiss; Marco A Marra; Hiromichi Suzuki; Michael D Taylor
Journal:  Nat Commun       Date:  2021-03-19       Impact factor: 17.694

4.  Wip1 Deficiency Promotes Neutrophil Recruitment to the Infection Site and Improves Sepsis Outcome.

Authors:  Xiao-Fei Shen; Yang Zhao; Ke Cao; Wen-Xian Guan; Xue Li; Qian Zhang; Yong Zhao; Yi-Tao Ding; Jun-Feng Du
Journal:  Front Immunol       Date:  2017-08-22       Impact factor: 7.561

5.  APPBP2 enhances non-small cell lung cancer proliferation and invasiveness through regulating PPM1D and SPOP.

Authors:  Huiyuan Gong; Fei Liu; Xiaoyu Liu; Shengping Min; Nan Wu; Xincheng Liu; Yueguang Liu; Sue Han; Yijie Zhang; Yuefang Zhang; Yudong Hu; Xuegang Liu; Xiaojing Wang
Journal:  EBioMedicine       Date:  2019-05-16       Impact factor: 8.143

Review 6.  Protein phosphatases in TLR signaling.

Authors:  Clovis H T Seumen; Tanja M Grimm; Christof R Hauck
Journal:  Cell Commun Signal       Date:  2021-04-21       Impact factor: 5.712

7.  PPM1D Is a Therapeutic Target in Childhood Neural Tumors.

Authors:  Jelena Milosevic; Diana Treis; Susanne Fransson; Gabriel Gallo-Oller; Baldur Sveinbjörnsson; Nina Eissler; Keiji Tanino; Kazuyasu Sakaguchi; Tommy Martinsson; Malin Wickström; Per Kogner; John Inge Johnsen
Journal:  Cancers (Basel)       Date:  2021-11-30       Impact factor: 6.639

8.  Potentiality of Protein phosphatase Mg2+ /Mn2+ dependent 1D as a biomarker for predicting prognosis in acute myeloid leukemia patients.

Authors:  Meijia Yu; Jie Hu; Di He; Qi Chen; Suna Liu; Xiaoling Zhu; Bin Li
Journal:  J Clin Lab Anal       Date:  2020-01-03       Impact factor: 2.352

9.  Clinical Implications of Sub-grouping HER2 Positive Tumors by Amplicon Structure and Co-amplified Genes.

Authors:  Myriam Maoz; Michal Devir; Michal Inbar; Ziva Inbar-Daniel; Dana Sherill-Rofe; Idit Bloch; Karen Meir; David Edelman; Salah Azzam; Hovav Nechushtan; Ofra Maimon; Beatrice Uziely; Luna Kadouri; Amir Sonnenblick; Amir Eden; Tamar Peretz; Aviad Zick
Journal:  Sci Rep       Date:  2019-12-11       Impact factor: 4.379
  9 in total

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