Şenol Çomoğlu1, Beldan Polat2, Mehmet Çelik3, Bayram Şahin4, Necati Enver5, Meryem Nesil Keleş6, Şule Öztürk Sarı7. 1. University of Istanbul, Istanbul Medical Faculty Department of Otorhinolaryngology-Head and Neck Surgery, Istanbul, Turkey. Electronic address: drcomoglu@gmail.com. 2. University of Istanbul, Istanbul Medical Faculty Department of Otorhinolaryngology-Head and Neck Surgery, Istanbul, Turkey. Electronic address: beldanmdpolat@gmail.com. 3. University of Istanbul, Istanbul Medical Faculty Department of Otorhinolaryngology-Head and Neck Surgery, Istanbul, Turkey. Electronic address: mehmetcelik34@hotmail.com. 4. University of Istanbul, Istanbul Medical Faculty Department of Otorhinolaryngology-Head and Neck Surgery, Istanbul, Turkey. Electronic address: drbayramsahin@gmail.com. 5. Marmara University, Department of Otorhinolaryngology-Head and Neck Surgery, Istanbul, Turkey. Electronic address: necatienver@gmail.com. 6. University of Istanbul, Istanbul Medical Faculty Department of Otorhinolaryngology-Head and Neck Surgery, Istanbul, Turkey. Electronic address: nkeles@yahoo.com. 7. University of Istanbul, Istanbul Medical Faculty Department of Pathology, Istanbul, Turkey. Electronic address: suleozturksari@gmail.com.
Abstract
OBJECTIVE: Primary mucosal malignant melanoma of the head and neck (HN-PMMM) is an aggressive and uncommon neoplasm. Herein, we present a series of 33 patients and the results of treatment, and aimed to determine prognostic factors in HN-PMMM. METHODS: Patients who were diagnosed as having HN-PMMM in our reference hospital, between 2005 and 2014 were evaluated. Thirty-three of these patients who had follow-up data were included. Surgical margin status was extracted from the original pathology reports. Archived materials were retrieved for the histopathologic findings: ulceration, necrosis, lymphovascular invasion, perineural invasion, pigmentation, and presence of an in situ component. Mitotic activity was evaluated using phosphohistone H3 (PHH3) immunohistochemical staining. RESULTS: We found an association of PHH3 mitotic activity with overall survival in a univariate analysis and to our knowledge, this is the first report among the available case series of HN-PMMM to evaluate mitotic activity using immunohistochemical staining. We also investigated the relationship between multicentricity and locoregional recurrence, which the authors believe is also a first. CONCLUSION: PHH3 mitotic activity can be used a prognostic factor for head and neck mucosal malignant melanoma.
OBJECTIVE:Primary mucosal malignant melanoma of the head and neck (HN-PMMM) is an aggressive and uncommon neoplasm. Herein, we present a series of 33 patients and the results of treatment, and aimed to determine prognostic factors in HN-PMMM. METHODS:Patients who were diagnosed as having HN-PMMM in our reference hospital, between 2005 and 2014 were evaluated. Thirty-three of these patients who had follow-up data were included. Surgical margin status was extracted from the original pathology reports. Archived materials were retrieved for the histopathologic findings: ulceration, necrosis, lymphovascular invasion, perineural invasion, pigmentation, and presence of an in situ component. Mitotic activity was evaluated using phosphohistoneH3 (PHH3) immunohistochemical staining. RESULTS: We found an association of PHH3 mitotic activity with overall survival in a univariate analysis and to our knowledge, this is the first report among the available case series of HN-PMMM to evaluate mitotic activity using immunohistochemical staining. We also investigated the relationship between multicentricity and locoregional recurrence, which the authors believe is also a first. CONCLUSION:PHH3 mitotic activity can be used a prognostic factor for head and neck mucosal malignant melanoma.