Salahuddin Siddiqui1, Sri Prakash Misra2, Manisha Dwivedi2, Sanjay Pant3. 1. Resident, Department of Internal Medicine, Allegheny Health Network Medical Education Consortium , Pittsburgh, Pennsylvania, USA . 2. Professor, Department of Gastroenterology and Hepatology, MLN Medical College , Allahabad, Uttar Pradesh, India . 3. Senior Resident, Department of Gastroenterology and Hepatology, MLN Medical College , Allahabad, Uttar Pradesh, India .
Abstract
INTRODUCTION: Irritable Bowel Syndrome (IBS), a common gastrointestinal (GI) disorder has been linked with asthma implying a clue to its pathophysiology as being some form of allergic response. Previous studies from other parts of the world have shown both the presence as well as an absence of an association between them. AIM: We conducted a cross-sectional study to find an association between IBS and asthma, in an Indian cohort. MATERIALS AND METHODS: Seventy patients of IBS diagnosed by exclusion and ROME III criteria with a matched control group were questioned for GI, respiratory symptoms along with their spirometry analysis. Those having reversible bronchoconstriction were categorized as asthmatic. RESULTS: The prevalence of asthma in the IBS group of 16 females and 54 males was 12 (17.14%) as compared to 14 (20%) in control group. Chi-square test revealed the Odds Ratio (OR) for prevalence of asthma in IBS as 0.828 with 95% Confidence Interval (CI) between 0.320 and 2.121 (p=0.664) which was non-significant (p>0.05). CONCLUSION: This study denies the presence of association between IBS and asthma among Indian cohorts and suggests that regional variations are present in the above association.
INTRODUCTION:Irritable Bowel Syndrome (IBS), a common gastrointestinal (GI) disorder has been linked with asthma implying a clue to its pathophysiology as being some form of allergic response. Previous studies from other parts of the world have shown both the presence as well as an absence of an association between them. AIM: We conducted a cross-sectional study to find an association between IBS and asthma, in an Indian cohort. MATERIALS AND METHODS: Seventy patients of IBS diagnosed by exclusion and ROME III criteria with a matched control group were questioned for GI, respiratory symptoms along with their spirometry analysis. Those having reversible bronchoconstriction were categorized as asthmatic. RESULTS: The prevalence of asthma in the IBS group of 16 females and 54 males was 12 (17.14%) as compared to 14 (20%) in control group. Chi-square test revealed the Odds Ratio (OR) for prevalence of asthma in IBS as 0.828 with 95% Confidence Interval (CI) between 0.320 and 2.121 (p=0.664) which was non-significant (p>0.05). CONCLUSION: This study denies the presence of association between IBS and asthma among Indian cohorts and suggests that regional variations are present in the above association.
Authors: Uday C Ghoshal; Philip Abraham; Chetan Bhatt; Gourdas Choudhuri; Shobna J Bhatia; K T Shenoy; N H Banka; Kalyan Bose; N P Bohidar; Karmabir Chakravartty; N Chandra Shekhar; Nutan Desai; Usha Dutta; Goutam Das; Sangeet Dutta; V K Dixit; B D Goswami; R K Jain; Sunil Jain; V Jayanthi; Rakesh Kochhar; Ajay Kumar; Govind Makharia; Shrikant V Mukewar; V G Mohan Prasad; Alok Mohanty; A T Mohan; B S Sathyaprakash; B Prabhakar; Mathew Philip; E Peda Veerraju; Gautam Ray; Ramesh Roop Rai; A K Seth; Atul Sachdeva; Shivaram Prasad Singh; Ajit Sood; Varghese Thomas; Shridhar Tiwari; Manu Tandan; R Upadhyay; J C Vij Journal: Indian J Gastroenterol Date: 2008 Jan-Feb