BACKGROUND: Our aim was to evaluate and compare the diagnostic properties of 5 screening tests for the diagnosis of mild Alzheimer disease (AD). METHODS: We conducted a prospective and cross-sectional study of 92 patients with mild AD and of 68 healthy controls from our Department of Neurology. The diagnostic properties of the following tests were compared: Mini-Mental State Examination (MMSE), Addenbrooke's Cognitive Examination III (ACE-III), Memory Impairment Screen (MIS), Montreal Cognitive Assessment (MoCA), and Rowland Universal Dementia Assessment Scale (RUDAS). RESULTS: All tests yielded high diagnostic accuracy, with the ACE-III achieving the best diagnostic properties. The area under the curve was 0.897 for the ACE-III, 0.889 for the RUDAS, 0.874 for the MMSE, 0.866 for the MIS, and 0.856 for the MoCA. The Mini-ACE score from the ACE-III showed the highest diagnostic capacity (area under the curve 0.939). Memory scores of the ACE-III and of the RUDAS showed a better diagnostic accuracy than those of the MMSE and of the MoCA. All tests, especially the ACE-III, conveyed a higher diagnostic accuracy in patients with full primary education than in the less educated group. Implementing normative data improved the diagnostic accuracy of the ACE-III but not that of the other tests. CONCLUSIONS: The ACE-III achieved the highest diagnostic accuracy. This better discrimination was more evident in the more educated group.
BACKGROUND: Our aim was to evaluate and compare the diagnostic properties of 5 screening tests for the diagnosis of mild Alzheimer disease (AD). METHODS: We conducted a prospective and cross-sectional study of 92 patients with mild AD and of 68 healthy controls from our Department of Neurology. The diagnostic properties of the following tests were compared: Mini-Mental State Examination (MMSE), Addenbrooke's Cognitive Examination III (ACE-III), Memory Impairment Screen (MIS), Montreal Cognitive Assessment (MoCA), and Rowland Universal Dementia Assessment Scale (RUDAS). RESULTS: All tests yielded high diagnostic accuracy, with the ACE-III achieving the best diagnostic properties. The area under the curve was 0.897 for the ACE-III, 0.889 for the RUDAS, 0.874 for the MMSE, 0.866 for the MIS, and 0.856 for the MoCA. The Mini-ACE score from the ACE-III showed the highest diagnostic capacity (area under the curve 0.939). Memory scores of the ACE-III and of the RUDAS showed a better diagnostic accuracy than those of the MMSE and of the MoCA. All tests, especially the ACE-III, conveyed a higher diagnostic accuracy in patients with full primary education than in the less educated group. Implementing normative data improved the diagnostic accuracy of the ACE-III but not that of the other tests. CONCLUSIONS: The ACE-III achieved the highest diagnostic accuracy. This better discrimination was more evident in the more educated group.
Authors: David F Tang-Wai; Eric E Smith; Marie-Andrée Bruneau; Amer M Burhan; Atri Chatterjee; Howard Chertkow; Samira Choudhury; Ehsan Dorri; Simon Ducharme; Corinne E Fischer; Sheena Ghodasara; Nathan Herrmann; Ging-Yuek Robin Hsiung; Sanjeev Kumar; Robert Laforce; Linda Lee; Fadi Massoud; Kenneth I Shulman; Michael Stiffel; Serge Gauthier; Zahinoor Ismail Journal: Alzheimers Dement (N Y) Date: 2020-11-11
Authors: Elizabeth E Blue; Joshua C Bis; Michael O Dorschner; Debby W Tsuang; Sandra M Barral; Gary Beecham; Jennifer E Below; William S Bush; Mariusz Butkiewicz; Carlos Cruchaga; Anita DeStefano; Lindsay A Farrer; Alison Goate; Jonathan Haines; Jim Jaworski; Gyungah Jun; Brian Kunkle; Amanda Kuzma; Jenny J Lee; Kathryn L Lunetta; Yiyi Ma; Eden Martin; Adam Naj; Alejandro Q Nato; Patrick Navas; Hiep Nguyen; Christiane Reitz; Dolly Reyes; William Salerno; Gerard D Schellenberg; Sudha Seshadri; Harkirat Sohi; Timothy A Thornton; Otto Valadares; Cornelia van Duijn; Badri N Vardarajan; Li-San Wang; Eric Boerwinkle; Josée Dupuis; Margaret A Pericak-Vance; Richard Mayeux; Ellen M Wijsman Journal: Dement Geriatr Cogn Disord Date: 2018-02-27 Impact factor: 2.959
Authors: Miriam Goudsmit; Jos van Campen; Thelma Schilt; Chris Hinnen; Sanne Franzen; Ben Schmand Journal: Dement Geriatr Cogn Dis Extra Date: 2018-08-29
Authors: Björn Weiss; Julius J Grunow; Max Rosenthal; David Hilfrich; Rudolf Mörgeli; Bruno Neuner; Friedrich Borchers; Antje Kraft; Henning Krampe; Claudia Denke; Claudia D Spies Journal: Ger Med Sci Date: 2020-04-06
Authors: José Wagner Leonel Tavares-Júnior; Ana Célia Caetano de Souza; Gilberto Sousa Alves; Janine de Carvalho Bonfadini; José Ibiapina Siqueira-Neto; Pedro Braga-Neto Journal: Front Psychiatry Date: 2019-12-13 Impact factor: 4.157