Literature DB >> 28383678

MicroRNA-mediated dynamic control of mucosal immunity.

Eun Jeong Park1,2, Motomu Shimaoka2, Hiroshi Kiyono1,3,4.   

Abstract

The gastrointestinal tract is a complex and important physiological and immunological organ embodying the first line of defense by which mucosal immunity regulates the immense number and diversity of naturally encountered antigens and commensal microflora. Effective microRNA (miRNA) control of transcription factors or mediators in mucosal immunity is essential to host defense and homeostasis in both physiologic and pathologic states. MiRNA biology has advanced our understanding of the immune regulatory system network at the level of post-transcriptional gene modification. Increasing knowledge on circulating miRNAs could potentially enhance diagnostic techniques in inflammatory bowel disease (IBD). Furthermore, recent findings on the dynamic role of exosomes vis-à-vis the intercellular transportation of miRNAs may provide insights on the use of miRNA as a target for treating IBD. © The Japanese Society for Immunology. 2017. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  IBD; IEC; exosome; intestine; microflora

Mesh：

Substances：

Year:  2017        PMID： 28383678     DOI： 10.1093/intimm/dxx019

Source DB:  PubMed          Journal:  Int Immunol        ISSN： 0953-8178            Impact factor:   4.823


  10 in total

Review 1.  Functional Flexibility of Exosomes and MicroRNAs of Intestinal Epithelial Cells in Affecting Inflammation.

Authors:  Eun Jeong Park; Motomu Shimaoka; Hiroshi Kiyono
Journal:  Front Mol Biosci       Date:  2022-05-11

2.  Autologous Exosome Transfer: A New Personalised Treatment Concept to Prevent Colitis in a Murine Model.

Authors:  Chunhua Yang; Mingzhen Zhang; Junsik Sung; Lixin Wang; Yunjin Jung; Didier Merlin
Journal:  J Crohns Colitis       Date:  2020-07-09       Impact factor: 9.071

3.  MDR1A deficiency restrains tumor growth in murine colitis-associated carcinogenesis.

Authors:  Eva Maria Hennenberg; Annette Eyking; Henning Reis; Elke Cario
Journal:  PLoS One       Date:  2017-07-07       Impact factor: 3.240

4.  miRNAs expression of oral squamous cell carcinoma patients: Validation of two putative biomarkers.

Authors:  Cintia Micaela Chamorro Petronacci; Mario Pérez-Sayáns; María Elena Padín Iruegas; José M Suárez Peñaranda; Alejandro Ismael Lorenzo Pouso; Andrés Blanco Carrión; Abel García García
Journal:  Medicine (Baltimore)       Date:  2019-03       Impact factor: 1.889

5.  Integrated Bioinformatics Analysis of mRNAs and miRNAs Identified Potential Biomarkers of Oral Squamous Cell Carcinoma.

Authors:  Nasrin Amiri-Dashatan; Mehdi Koushki; Ali Jalilian; Nayeb Ali Ahmadi; Mostafa Rezaei-Tavirani
Journal:  Asian Pac J Cancer Prev       Date:  2020-06-29

6.  miR-511 Deficiency Protects Mice from Experimental Colitis by Reducing TLR3 and TLR4 Responses via WD Repeat and FYVE-Domain-Containing Protein 1.

Authors:  Shafaque Rahman; Jolien Vandewalle; Patricia H P van Hamersveld; Caroline Verseijden; Olaf Welting; Aldo Jongejan; Pierina Casanova; Sybren L Meijer; Claude Libert; Theodorus B M Hakvoort; Wouter J de Jonge; Sigrid E M Heinsbroek
Journal:  Cells       Date:  2021-12-25       Impact factor: 6.600

7.  miR-21 antagonist alleviates colitis and angiogenesis via the PTEN/PI3K/AKT pathway in colitis mice induced by TNBS.

Authors:  Xiaoran Xie; Peng Liu; Hao Wu; Huan Li; Yu Tang; Xiong Chen; Canxia Xu; Xiaoming Liu; Guoyu Dai
Journal:  Ann Transl Med       Date:  2022-04

8.  Dietary Soy Protein Isolate Attenuates Intestinal Immunoglobulin and Mucin Expression in Young Mice Compared with Casein.

Authors:  Bin Zeng; Dongyang Wang; Hailong Wang; Ting Chen; Junyi Luo; Qianyun Xi; Jiajie Sun; Yongliang Zhang
Journal:  Nutrients       Date:  2020-09-08       Impact factor: 5.717

9.  Exosome-mediated effects and applications in inflammatory bowel disease.

Authors:  Dickson K W Ocansey; Li Zhang; Yifei Wang; Yongmin Yan; Hui Qian; Xu Zhang; Wenrong Xu; Fei Mao
Journal:  Biol Rev Camb Philos Soc       Date:  2020-05-14

10.  Distinct Age-Specific miRegulome Profiling of Isolated Small and Large Intestinal Epithelial Cells in Mice.

Authors:  Juneyoung Lee; Attayeb Mohsen; Anik Banerjee; Louise D McCullough; Kenji Mizuguchi; Motomu Shimaoka; Hiroshi Kiyono; Eun Jeong Park
Journal:  Int J Mol Sci       Date:  2021-03-29       Impact factor: 5.923
  10 in total

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