Literature DB >> 283836

Defective hydrogen peroxide production in chronic granulocytic leukaemia neutrophils.

H El-Maallem, J Fletcher.   

Abstract

Hydrogen peroxide (H2O2) production by polymorphonuclear neutrophils (PMN) during phagocytosis was fluorometrically vestimated over an incubation period of 80 min during which dead Candida guilliermondii were ingested. Ten patients with chronic granulocytic leukaemia (CGL) were tested and compared with 15 normal subjects. The production of H2O2 by CGL neutrophils was about 29% of normal. There was no correlation between H2O2 production and the impaired killing of Candida guilliermondii by the neutrophils of CGL patients.

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Year:  1979        PMID: 283836     DOI: 10.1111/j.1365-2141.1979.tb03680.x

Source DB:  PubMed          Journal:  Br J Haematol        ISSN: 0007-1048            Impact factor:   6.998


  3 in total

1.  Electron microscopic cytochemical localization of nucleoside phosphatases in normal and chronic granulocytic leukaemic human neutrophils.

Authors:  P D Wilson; G J Rustin; G P Smith; T J Peters
Journal:  Histochem J       Date:  1981-01

2.  A new neutrophil candida killing test: chromium-51 release from Candida guilliermondii.

Authors:  S Martin; A T Ghoneim; J A Child
Journal:  J Clin Pathol       Date:  1980-08       Impact factor: 3.411

3.  Leukotriene B4 synthesis and neutrophil chemotaxis in chronic granulocytic leukaemia.

Authors:  I A Reilly; H R Knapp; G A Fitzgerald
Journal:  J Clin Pathol       Date:  1988-11       Impact factor: 3.411

  3 in total

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