Literature DB >> 2838334

Oxidation of uroporphyrinogens by hydroxyl radicals. Evidence for nonporphyrin products as potential inhibitors of uroporphyrinogen decarboxylase.

J E Francis1, A G Smith.   

Abstract

A hydroxyl radical-generating system, hypoxanthine/xanthine oxidase/Fe-EDTA, oxidises uroporphyrinogens to uroporphyrins and to more polar nonporphyrin products. The evidence suggests that the nonporphyrin products have inhibitory activity towards mouse liver uroporphyrinogen decarboxylase which could explain some forms of human and experimental porphyrias.

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Year:  1988        PMID： 2838334     DOI： 10.1016/0014-5793(88)80449-6

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  6 in total

1.  Inhibition of uroporphyrinogen decarboxylase activity. The role of cytochrome P-450-mediated uroporphyrinogen oxidation.

Authors:  R W Lambrecht; J M Jacobs; P R Sinclair; J F Sinclair
Journal:  Biochem J       Date:  1990-07-15       Impact factor: 3.857

2.  Porphyria cutanea tarda: multiplicity of risk factors including HFE mutations, hepatitis C, and inherited uroporphyrinogen decarboxylase deficiency.

Authors:  Norman G Egger; Douglas E Goeger; Deborah A Payne; Emil P Miskovsky; Steven A Weinman; Karl E Anderson
Journal:  Dig Dis Sci       Date:  2002-02       Impact factor: 3.199

Review 3.  Uroporphyrinogen decarboxylase.

Authors:  G H Elder; A G Roberts
Journal:  J Bioenerg Biomembr       Date:  1995-04       Impact factor: 2.945

4.  Genetic variation of iron-induced uroporphyria in mice.

Authors:  A G Smith; J E Francis
Journal:  Biochem J       Date:  1993-04-01       Impact factor: 3.857

Review 5.  The association between chemical-induced porphyria and hepatic cancer.

Authors:  Andrew G Smith; John R Foster
Journal:  Toxicol Res (Camb)       Date:  2018-06-01       Impact factor: 3.524

6.  Systematic identification and analysis of frequent gene fusion events in metabolic pathways.

Authors:  Christopher S Henry; Claudia Lerma-Ortiz; Svetlana Y Gerdes; Jeffrey D Mullen; Ric Colasanti; Aleksey Zhukov; Océane Frelin; Jennifer J Thiaville; Rémi Zallot; Thomas D Niehaus; Ghulam Hasnain; Neal Conrad; Andrew D Hanson; Valérie de Crécy-Lagard
Journal:  BMC Genomics       Date:  2016-06-24       Impact factor: 3.969
  6 in total

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