Literature DB >> 2838160

Regional chromosome localization of human papillomavirus integration sites near fragile sites, oncogenes, and cancer chromosome breakpoints.

L A Cannizzaro1, M Dürst, M J Mendez, B K Hecht, F Hecht.   

Abstract

The integration sites of human papillomavirus (HPV) DNA within the cervical carcinoma cell line C4-I and a primary cervical tumor were mapped by in situ hybridization. Cloned cellular sequences flanking the integrated viral DNA were used as probes. For the cell line, the viral integration site was mapped to chromosome region 8q21-q22.3, while in the primary tumor chromosome band 3p21 was the target for integration. The HPV DNA integration appears to occur in the vicinity of fragile sites, oncogenes, and chromosome breakpoints that are characteristic of hematologic malignancies and solid tumors. The integration of HPV may thus promote chromosome changes in cancer cells.

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Year:  1988        PMID： 2838160     DOI： 10.1016/0165-4608(88)90054-4

Source DB:  PubMed          Journal:  Cancer Genet Cytogenet        ISSN： 0165-4608


  15 in total

1.  Localization of the human HF.10 finger gene on a chromosome region (3p21-22) frequently deleted in human cancers.

Authors:  E Donti; L Lanfrancone; K Huebner; A Pascucci; G Venti; G Pengue; F Grignani; C M Croce; L Lania; P G Pelicci
Journal:  Hum Genet       Date:  1990-04       Impact factor: 4.132

2.  Integration of papillomavirus DNA near myc genes in genital carcinomas and its consequences for proto-oncogene expression.

Authors:  J Couturier; X Sastre-Garau; S Schneider-Maunoury; A Labib; G Orth
Journal:  J Virol       Date:  1991-08       Impact factor: 5.103

3.  Human papilloma virus DNA exposure and embryo survival is stage-specific.

Authors:  Andrew A Henneberg; William C Patton; John D Jacobson; Philip J Chan
Journal:  J Assist Reprod Genet       Date:  2006-07-27       Impact factor: 3.412

4.  The SMC5/6 Complex Interacts with the Papillomavirus E2 Protein and Influences Maintenance of Viral Episomal DNA.

Authors:  Peris Bentley; Min Jie Alvin Tan; Alison A McBride; Elizabeth A White; Peter M Howley
Journal:  J Virol       Date:  2018-07-17       Impact factor: 5.103

5.  Identification of two cosmids derived from within chromosomal band 3p21.1 that contain clusters of rare restriction sites and evolutionarily conserved sequences.

Authors:  D I Smith; W Golembieski; H Drabkin; S Kiousis
Journal:  Am J Hum Genet       Date:  1989-09       Impact factor: 11.025

6.  Sequence of the FRA3B common fragile region: implications for the mechanism of FHIT deletion.

Authors:  H Inoue; H Ishii; H Alder; E Snyder; T Druck; K Huebner; C M Croce
Journal:  Proc Natl Acad Sci U S A       Date:  1997-12-23       Impact factor: 11.205

7.  Squamous metaplasia induced by transfection of human papillomavirus DNA into cultured adenocarcinoma cells.

Authors:  T Kinjo; K Kamiyama; K Chinen; T Iwamasa; K Kurihara; T Hamada
Journal:  Mol Pathol       Date:  2003-04

8.  APM-1, a novel human gene, identified by aberrant co-transcription with papillomavirus oncogenes in a cervical carcinoma cell line, encodes a BTB/POZ-zinc finger protein with growth inhibitory activity.

Authors:  S Reuter; M Bartelmann; M Vogt; C Geisen; I Napierski; T Kahn; H Delius; P Lichter; S Weitz; B Korn; E Schwarz
Journal:  EMBO J       Date:  1998-01-02       Impact factor: 11.598

9.  Laser scanning confocal microscopy and quantitative microscopy with a charge coupled device camera improve detection of human papillomavirus DNA revealed by fluorescence in situ hybridization.

Authors:  G Lizard; M C Chignol; C Souchier; D Schmitt; Y Chardonnet
Journal:  Histochemistry       Date:  1994-04

10.  Viral integration, fragile sites, and proto-oncogenes in human neoplasia.

Authors:  N C Popescu; D Zimonjic; J A DiPaolo
Journal:  Hum Genet       Date:  1990-04       Impact factor: 4.132
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