Carlos Celis-Morales1,2, Cyril Fm Marsaux3, Katherine M Livingstone1, Santiago Navas-Carretero4, Rodrigo San-Cristobal4, Rosalind Fallaize5, Anna L Macready5, Clare O'Donovan6, Clara Woolhead6, Hannah Forster6, Silvia Kolossa7, Hannelore Daniel7, George Moschonis8, Christina Mavrogianni8, Yannis Manios8, Agnieszka Surwillo9, Iwona Traczyk9, Christian A Drevon10, Keith Grimaldi11, Jildau Bouwman12, Mike J Gibney6, Marianne C Walsh6, Eileen R Gibney6, Lorraine Brennan6, Julie A Lovegrove5, J Alfredo Martinez4, Wim Hm Saris3, John C Mathers13. 1. Human Nutrition Research Center, Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, United Kingdom. 2. Glasgow Cardiovascular Research Center, Institute of Cardiovascular and Medical Science, University of Glasgow, Glasgow, United Kingdom. 3. Department of Human Biology, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University Medical Center, Maastricht, Netherlands. 4. Department of Nutrition, Food Science and Physiology, Center for Nutrition Research, University of Navarra, Pamplona, Spain. 5. Hugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular and Metabolic Research, University of Reading, Reading, United Kingdom. 6. University College Dublin (UCD) Institute of Food and Health, UCD, Dublin, Ireland. 7. Research Center of Nutrition and Food Sciences (ZIEL), Biochemistry Unit, Technical University of Munich, Munich, Germany. 8. Department of Nutrition and Dietetics, Harokopio University, Athens, Greece. 9. National Food and Nutrition Institute, Warsaw, Poland. 10. Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway. 11. Eurogenetica Ltd, Burnham-on-Sea, United Kingdom; and. 12. Netherlands Organization for Applied Scientific Research (TNO), Microbiology and Systems Biology Group, Zeist, Netherlands. 13. Human Nutrition Research Center, Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, United Kingdom; john.mathers@ncl.ac.uk.
Abstract
Background: There has been limited evidence about whether genotype-tailored advice provides extra benefits in reducing obesity-related traits compared with the benefits of conventional one-size-fits-all advice.Objective: We determined whether the disclosure of information on fat-mass and obesity-associated (FTO) genotype risk had a greater effect on a reduction of obesity-related traits in risk carriers than in nonrisk carriers across different levels of personalized nutrition.Design: A total of 683 participants (women: 51%; age range: 18-73 y) from the Food4Me randomized controlled trial were included in this analysis. Participants were randomly assigned to 4 intervention arms as follows: level 0, control group; level 1, dietary group; level 2, phenotype group; and level 3, genetic group. FTO (single nucleotide polymorphism rs9939609) was genotyped at baseline in all participants, but only subjects who were randomly assigned to level 3 were informed about their genotypes. Level 3 participants were stratified into risk carriers (AA/AT) and nonrisk carriers (TT) of the FTO gene for analyses. Height, weight, and waist circumference (WC) were self-measured and reported at baseline and months 3 and 6. Results: Changes in adiposity markers were greater in participants who were informed that they carried the FTO risk allele (level 3 AT/AA carriers) than in the nonpersonalized group (level 0) but not in the other personalized groups (level 1 and 2). Mean reductions in weight and WC at month 6 were greater for FTO risk carriers than for noncarriers in the level 3 group [-2.28 kg (95% CI: -3.06, -1.48 kg) compared with -1.99 kg (-2.19, -0.19 kg), respectively (P = 0.037); and -4.34 cm (-5.63, -3.08 cm) compared with -1.99 cm (-4.04, -0.05 cm), respectively, (P = 0.048)].Conclusions: There are greater body weight and WC reductions in risk carriers than in nonrisk carriers of the FTO gene. This trial was registered at clinicaltrials.gov as NCT01530139.
RCT Entities:
Background: There has been limited evidence about whether genotype-tailored advice provides extra benefits in reducing obesity-related traits compared with the benefits of conventional one-size-fits-all advice.Objective: We determined whether the disclosure of information on fat-mass and obesity-associated (FTO) genotype risk had a greater effect on a reduction of obesity-related traits in risk carriers than in nonrisk carriers across different levels of personalized nutrition.Design: A total of 683 participants (women: 51%; age range: 18-73 y) from the Food4Me randomized controlled trial were included in this analysis. Participants were randomly assigned to 4 intervention arms as follows: level 0, control group; level 1, dietary group; level 2, phenotype group; and level 3, genetic group. FTO (single nucleotide polymorphism rs9939609) was genotyped at baseline in all participants, but only subjects who were randomly assigned to level 3 were informed about their genotypes. Level 3 participants were stratified into risk carriers (AA/AT) and nonrisk carriers (TT) of the FTO gene for analyses. Height, weight, and waist circumference (WC) were self-measured and reported at baseline and months 3 and 6. Results: Changes in adiposity markers were greater in participants who were informed that they carried the FTO risk allele (level 3 AT/AA carriers) than in the nonpersonalized group (level 0) but not in the other personalized groups (level 1 and 2). Mean reductions in weight and WC at month 6 were greater for FTO risk carriers than for noncarriers in the level 3 group [-2.28 kg (95% CI: -3.06, -1.48 kg) compared with -1.99 kg (-2.19, -0.19 kg), respectively (P = 0.037); and -4.34 cm (-5.63, -3.08 cm) compared with -1.99 cm (-4.04, -0.05 cm), respectively, (P = 0.048)].Conclusions: There are greater body weight and WC reductions in risk carriers than in nonrisk carriers of the FTO gene. This trial was registered at clinicaltrials.gov as NCT01530139.
Authors: Juntao Kan; Jiayi Ni; Kun Xue; Feijie Wang; Jianheng Zheng; Junrui Cheng; Peiying Wu; Matthew K Runyon; Hongwei Guo; Jun Du Journal: Front Nutr Date: 2022-06-22
Authors: Rodrigo San-Cristobal; Santiago Navas-Carretero; Carlos Celis-Morales; Katherine M Livingstone; Barbara Stewart-Knox; Audrey Rankin; Anna L Macready; Rosalind Fallaize; Clare B O'Donovan; Hannah Forster; Clara Woolhead; Marianne C Walsh; Christina P Lambrinou; George Moschonis; Yannis Manios; Miroslaw Jarosz; Hannelore Daniel; Eileen R Gibney; Lorraine Brennan; Thomas E Gundersen; Christian A Drevon; Mike Gibney; Cyril F M Marsaux; Wim H M Saris; Julie A Lovegrove; Lynn J Frewer; John C Mathers; J Alfredo Martinez Journal: Int J Behav Nutr Phys Act Date: 2017-12-11 Impact factor: 6.457
Authors: Katherine M Livingstone; Carlos Celis-Morales; Santiago Navas-Carretero; Rodrigo San-Cristobal; Hannah Forster; Clara Woolhead; Clare B O'Donovan; George Moschonis; Yannis Manios; Iwona Traczyk; Thomas E Gundersen; Christian A Drevon; Cyril F M Marsaux; Rosalind Fallaize; Anna L Macready; Hannelore Daniel; Wim H M Saris; Julie A Lovegrove; Mike Gibney; Eileen R Gibney; Marianne Walsh; Lorraine Brennan; J Alfredo Martinez; John C Mathers Journal: Int J Behav Nutr Phys Act Date: 2021-06-07 Impact factor: 6.457
Authors: Theresa Drabsch; Jennifer Gatzemeier; Lisa Pfadenhauer; Hans Hauner; Christina Holzapfel Journal: Adv Nutr Date: 2018-07-01 Impact factor: 8.701