| Literature DB >> 28381198 |
Yilong Wang1,2,3,4, Yi Lin5, Xia Meng1,2,3,4, Weiqi Chen1,2,3,4, Guohua Chen6, Zhimin Wang7, Jialing Wu8, Dali Wang9, Jianhua Li10, Yibin Cao11, Yuming Xu12, Guohua Zhang13, Xiaobo Li14, Yuesong Pan1,2,3,4, Hao Li1,2,3,4, Liping Liu1,2,3,4, Xingquan Zhao1,2,3,4, Yongjun Wang1,2,3,4.
Abstract
Rationale and aim Little is known about the safety and efficacy of the combination of ticagrelor and aspirin in acute ischemic stroke. This study aimed to evaluate whether the combination of ticagrelor and aspirin was superior to that of clopidogrel and aspirin in reducing the 90-day high on-treatment platelet reactivity for acute minor stroke or transient ischemic attack, especially for carriers of cytochrome P450 2C19 loss-of-function allele. Sample size and design This study was designed as a prospective, multicenter, randomized, open-label, active-controlled, and blind-endpoint, phase II b trial. The required sample size was 952 patients. It was registered with ClinicalTrials.gov (NCT02506140). Study outcomes The primary outcome was the proportion of patients with high on-treatment platelet reactivity at 90 days. High on-treatment platelet reactivity is defined as the P2Y12 reaction unit >208 measured using the VerifyNow P2Y12 assay. Conclusion The Platelet Reactivity in Acute Non-disabling Cerebrovascular Events study explored whether ticagrelor combined with aspirin could reduce further the proportion of patients with high on-treatment platelet reactivity at 90 days after acute minor stroke or transient ischemic attack compared with clopidogrel and aspirin.Entities:
Keywords: Clopidogrel; minor stroke; platelet reactivity; protocol; ticagrelor; transient ischemic attack
Mesh：
Substances：
Year: 2017 PMID： 28381198 DOI： 10.1177/1747493017694390
Source DB: PubMed Journal: Int J Stroke ISSN： 1747-4930 Impact factor: 5.266