Literature DB >> 28381182

Involvement of miR-125a in resistance to daunorubicin by inhibiting apoptosis in leukemia cell lines.

Haitao Bai1, Lili Zhou2, Chun Wang1, Xiaowei Xu1, Jieling Jiang1, Youwen Qin1, Xiaorui Wang1, Chuxian Zhao1, Shan Shao1.   

Abstract

In this study, we investigated whether miR-125a participated in the resistance of the leukemia cell lines to the chemotherapeutic agent daunorubicin. Higher expression of miR-125a is correlated with lower treatment response and shorter overall survival in acute leukemia patients. Overexpression of miR-125a induced drug resistance in HL-60, K562, and THP-1cell lines through reducing apoptosis. We also showed that miR-125a mediated daunorubicin resistance in leukemia cell lines through the decrease of GRK2 and Puma which were proved to be direct targets of miR-125a. This study may provide novel therapeutic targets for therapy and improve predictions of therapeutic responses in leukemia to daunorubicin.

Entities:  

Keywords:  MicroRNA-125a; apoptosis; daunorubicin; leukemia

Mesh：

Substances：

Year:  2017        PMID： 28381182     DOI： 10.1177/1010428317695964

Source DB:  PubMed          Journal:  Tumour Biol        ISSN： 1010-4283


  6 in total

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