| Literature DB >> 2838079 |
A S Janoff1, C L Kurtz, R L Jablonski, S R Minchey, L T Boni, S M Gruner, P R Cullis, L D Mayer, M J Hope.
Abstract
Cholesterol hemisuccinate (CHS) and alpha-tocopherol hemisuccinate (alpha-THS) were found to be capable of forming liposomes of multi- or single lamellar character. Such vesicles formed spontaneously, did not require the use of organic solvents and yielded high trapping efficiencies and captured volumes. Both CHS and alpha-THS systems greatly restricted the motion of intercalated spin labelled fatty acids, yet were more osmotically responsive than similar vesicle types comprised of phosphatidylcholine. Small angle X-ray diffraction measurements were consistent with vesicles possessing extremely weak interlamellar forces. CHS vesicles were found to remain intact in vivo, yet followed a pattern of distribution dissimilar to phosphatidylcholine vesicles.Entities:
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Year: 1988 PMID： 2838079 DOI： 10.1016/0005-2736(88)90177-0
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002