Literature DB >> 28380337

What's in an Average? An Ensemble View of Phosphorylation Effects.

Alexander F Chin1, Vincent J Hilser2.   

Abstract

The number of examples of functional post-translational modulation of disordered proteins rapidly grows. In a recent issue of Structure, Jie et al. (2017) show that phosphorylation of dynein intermediate chain alters partner binding but retains its dynamic, disorder character. An ensemble model offers an organizing framework to relate function, conformation, and phosphorylation in disordered and ordered proteins alike.
Copyright © 2017 Elsevier Ltd. All rights reserved.

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Year:  2017        PMID： 28380337      PMCID： PMC5822714          DOI： 10.1016/j.str.2017.03.012

Source DB:  PubMed          Journal:  Structure        ISSN： 0969-2126            Impact factor:   5.006


  10 in total

1.  Conformations of intrinsically disordered proteins are influenced by linear sequence distributions of oppositely charged residues.

Authors:  Rahul K Das; Rohit V Pappu
Journal:  Proc Natl Acad Sci U S A       Date:  2013-07-30       Impact factor: 11.205

2.  Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch.

Authors:  Alaji Bah; Robert M Vernon; Zeba Siddiqui; Mickaël Krzeminski; Ranjith Muhandiram; Charlie Zhao; Nahum Sonenberg; Lewis E Kay; Julie D Forman-Kay
Journal:  Nature       Date:  2014-12-22       Impact factor: 49.962

3.  Structural polymorphism in the N-terminal oligomerization domain of NPM1.

Authors:  Diana M Mitrea; Christy R Grace; Marija Buljan; Mi-Kyung Yun; Nicholas J Pytel; John Satumba; Amanda Nourse; Cheon-Gil Park; M Madan Babu; Stephen W White; Richard W Kriwacki
Journal:  Proc Natl Acad Sci U S A       Date:  2014-03-10       Impact factor: 11.205

Review 4.  The effects of phosphorylation on the structure and function of proteins.

Authors:  L N Johnson; D Barford
Journal:  Annu Rev Biophys Biomol Struct       Date:  1993

5.  Dynein Binding of Competitive Regulators Dynactin and NudE Involves Novel Interplay between Phosphorylation Site and Disordered Spliced Linkers.

Authors:  Jing Jie; Frank Löhr; Elisar Barbar
Journal:  Structure       Date:  2017-02-02       Impact factor: 5.006

Review 6.  The ensemble nature of allostery.

Authors:  Hesam N Motlagh; James O Wrabl; Jing Li; Vincent J Hilser
Journal:  Nature       Date:  2014-04-17       Impact factor: 49.962

7.  Site-specific phosphorylation induces functionally active conformation in the intrinsically disordered N-terminal activation function (AF1) domain of the glucocorticoid receptor.

Authors:  Anna M S Garza; Shagufta H Khan; Raj Kumar
Journal:  Mol Cell Biol       Date:  2010-01       Impact factor: 4.272

8.  Prediction and functional analysis of native disorder in proteins from the three kingdoms of life.

Authors:  J J Ward; J S Sodhi; L J McGuffin; B F Buxton; D T Jones
Journal:  J Mol Biol       Date:  2004-03-26       Impact factor: 5.469

9.  The importance of intrinsic disorder for protein phosphorylation.

Authors:  Lilia M Iakoucheva; Predrag Radivojac; Celeste J Brown; Timothy R O'Connor; Jason G Sikes; Zoran Obradovic; A Keith Dunker
Journal:  Nucleic Acids Res       Date:  2004-02-11       Impact factor: 16.971

10.  Regulation of RNA granule dynamics by phosphorylation of serine-rich, intrinsically disordered proteins in C. elegans.

Authors:  Jennifer T Wang; Jarrett Smith; Bi-Chang Chen; Helen Schmidt; Dominique Rasoloson; Alexandre Paix; Bramwell G Lambrus; Deepika Calidas; Eric Betzig; Geraldine Seydoux
Journal:  Elife       Date:  2014-12-23       Impact factor: 8.140
  10 in total

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