Literature DB >> 2837978

Changes in benzodiazepine receptors in Alzheimer-type dementia.

S Shimohama1, T Taniguchi, M Fujiwara, M Kameyama.   

Abstract

We studied benzodiazepine receptors in brains obtained at autopsy from 7 normal controls and 7 patients with Alzheimer-type dementia, using 3H-flunitrazepam as a ligand. Compared with controls, 3H-flunitrazepam binding sites were significantly reduced in number in frontal and temporal cortex and hippocampus in the Alzheimer-type dementia brains. These results suggest that there are significant changes in the number of benzodiazepine receptors in selected brain regions of patients with Alzheimer-type dementia.

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Year:  1988        PMID： 2837978     DOI： 10.1002/ana.410230419

Source DB:  PubMed          Journal:  Ann Neurol        ISSN： 0364-5134            Impact factor:   10.422


  9 in total

1.  Parvalbumin-Positive Neuron Loss and Amyloid-β Deposits in the Frontal Cortex of Alzheimer's Disease-Related Mice.

Authors:  Farhan Ali; Stephanie L Baringer; Arianna Neal; Esther Y Choi; Alex C Kwan
Journal:  J Alzheimers Dis       Date:  2019       Impact factor: 4.472

2.  SPECT imaging of GABA(A)/benzodiazepine receptors and cerebral perfusion in mild cognitive impairment.

Authors:  Sabina Pappatà; Andrea Varrone; Caterina Vicidomini; Graziella Milan; Caterina De Falco; Valeria Sansone; Alessandro Iavarone; Marco Comerci; Elisa Loré; Maria Rosaria Panico; Mario Quarantelli; Alfredo Postiglione; Marco Salvatore
Journal:  Eur J Nucl Med Mol Imaging       Date:  2010-03-20       Impact factor: 9.236

3.  An immunohistochemical study of GABA A receptor gamma subunits in Alzheimer's disease hippocampus: relationship to neurofibrillary tangle progression.

Authors:  Masahiko Iwakiri; Katsuyoshi Mizukami; Milos D Ikonomovic; Masanori Ishikawa; Eric E Abrahamson; Steven T DeKosky; Takashi Asada
Journal:  Neuropathology       Date:  2008-11-19       Impact factor: 1.906

4.  Risk of dementia in patients with insomnia and long-term use of hypnotics: a population-based retrospective cohort study.

Authors:  Pin-Liang Chen; Wei-Ju Lee; Wei-Zen Sun; Yen-Jen Oyang; Jong-Ling Fuh
Journal:  PLoS One       Date:  2012-11-07       Impact factor: 3.240

Review 5.  Use of Benzodiazepines in Alzheimer's Disease: A Systematic Review of Literature.

Authors:  Michaela Defrancesco; Josef Marksteiner; W Wolfgang Fleischhacker; Imrich Blasko
Journal:  Int J Neuropsychopharmacol       Date:  2015-05-19       Impact factor: 5.176

6.  Association between Benzodiazepine Use and Dementia: Data Mining of Different Medical Databases.

Authors:  Mitsutaka Takada; Mai Fujimoto; Kouichi Hosomi
Journal:  Int J Med Sci       Date:  2016-10-18       Impact factor: 3.738

Review 7.  Towards a Better Understanding of GABAergic Remodeling in Alzheimer's Disease.

Authors:  Karan Govindpani; Beatriz Calvo-Flores Guzmán; Chitra Vinnakota; Henry J Waldvogel; Richard L Faull; Andrea Kwakowsky
Journal:  Int J Mol Sci       Date:  2017-08-21       Impact factor: 5.923

Review 8.  Significance of GABAA Receptor for Cognitive Function and Hippocampal Pathology.

Authors:  Yuya Sakimoto; Paw Min-Thein Oo; Makoto Goshima; Itsuki Kanehisa; Yutaro Tsukada; Dai Mitsushima
Journal:  Int J Mol Sci       Date:  2021-11-18       Impact factor: 5.923

9.  Benzodiazepine use and risk of Alzheimer's disease: case-control study.

Authors:  Sophie Billioti de Gage; Yola Moride; Thierry Ducruet; Tobias Kurth; Hélène Verdoux; Marie Tournier; Antoine Pariente; Bernard Bégaud
Journal:  BMJ       Date:  2014-09-09
  9 in total

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