The role of leukotrienes in allergen-induced late responses in allergic sheep.

Evidence has been presented that lipoxygenase products of arachidonic acid metabolism released during the early stages of allergic reactions play an important role in the subsequent development of late bronchial responses. Moreover, because of this, the activity of the lipoxygenase pathway and sensitivity to the products generated may be important factors that distinguish between dual and acute responders. We recognize that these studies were performed in an experimental animal model of allergic airway disease. If the same mechanisms that are active in sheep are proven active in humans, then pharmacologic modification of the lipoxygenase pathway or its products (or both) may be important for the treatment of some forms of asthma.