Yu Luo1, Feng Liu2, Huadong Liu2, Hongdan Chen2, Wenfei Cheng2, Shaohong Dong2, Wei Xiong2. 1. Department of Gerontology, The Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, No.1017 Dongmen North Road, Shenzhen, 518020, PR China. 2. Department of Cardiology, The Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, No.1017 Dongmen North Road, Shenzhen, 518020, PR China.
Abstract
AIM: To investigate the changes and significance of circulating IL-39 in patients with acute coronary syndrome (ACS). PATIENTS & METHODS: Serum IL-39 levels in ACS patients and normal coronary arteries were measured. The correlations of IL-39 with high-sensitivity CRP, cTnI, N-terminal of the prohormone brain natriuretic peptide (NTproBNP) and left ventricular ejection fraction were investigated. RESULTS: The serum levels of IL-39 in ACS patients were significantly increased. IL-39 levels were positively correlated with NTproBNP, high-sensitivity CRP and cTnI, negatively correlated with left ventricular ejection fraction in ACS patients. The most significant correlation arose between serum IL-39 and NTproBNP in STEMI patients (r = 0.8309; p < 0.0001). CONCLUSION: Circulating level of IL-39 might be a predictor of cardiac systolic dysfunction in ST-segment elevation myocardial infarction patients.
AIM: To investigate the changes and significance of circulating IL-39 in patients with acute coronary syndrome (ACS). PATIENTS & METHODS: Serum IL-39 levels in ACS patients and normal coronary arteries were measured. The correlations of IL-39 with high-sensitivity CRP, cTnI, N-terminal of the prohormone brain natriuretic peptide (NTproBNP) and left ventricular ejection fraction were investigated. RESULTS: The serum levels of IL-39 in ACS patients were significantly increased. IL-39 levels were positively correlated with NTproBNP, high-sensitivity CRP and cTnI, negatively correlated with left ventricular ejection fraction in ACS patients. The most significant correlation arose between serum IL-39 and NTproBNP in STEMI patients (r = 0.8309; p < 0.0001). CONCLUSION: Circulating level of IL-39 might be a predictor of cardiac systolic dysfunction in ST-segment elevation myocardial infarctionpatients.
Entities:
Keywords:
IL-39; ST segment elevation myocardial infarction; acute coronary syndrome; biomarker; inflammation; left ventricular systolic dysfunction