Literature DB >> 28378934

Therapeutic potential of chemically modified siRNA: Recent trends.

Chelliah Selvam1, Daniel Mutisya2, Sandhya Prakash3, Kasturi Ranganna1, Ramasamy Thilagavathi3.   

Abstract

Small interfering RNAs (siRNAs) are one of the valuable tools to investigate the functions of genes and are also used for gene silencing. It has a wide scope in drug discovery through in vivo target validation. siRNA therapeutics are not optimal drug-like molecules due to poor bioavailability and immunogenic and off-target effects. To overcome the challenges associated with siRNA therapeutics, identification of appropriate chemical modifications that improves the stability, specificity and potency of siRNA is essential. This review focuses on the various chemical modifications and their implications in siRNA therapy.
© 2017 John Wiley & Sons A/S.

Entities:  

Keywords:  chemically modified siRNA; siRNA binding; siRNA therapeutics

Mesh：

Substances：

Year:  2017        PMID： 28378934      PMCID： PMC5935465          DOI： 10.1111/cbdd.12993

Source DB:  PubMed          Journal:  Chem Biol Drug Des        ISSN： 1747-0277            Impact factor:   2.817


  57 in total

1.  RNA interference in mammalian cells by chemically-modified RNA.

Authors:  Dwaine A Braasch; Susan Jensen; Yinghui Liu; Kiran Kaur; Khalil Arar; Michael A White; David R Corey
Journal:  Biochemistry       Date:  2003-07-08       Impact factor: 3.162

Review 2.  RNA interference as a gene-specific approach for molecular medicine.

Authors:  A Grünweller; R K Hartmann
Journal:  Curr Med Chem       Date:  2005       Impact factor: 4.530

3.  Silencing activity of 2'-O-methyl modified anti-MDR1 siRNAs with mismatches in the central part of the duplexes.

Authors:  Natalya S Petrova; Mariya I Meschaninova; Alya G Venyaminova; Marina A Zenkova; Valentin V Vlassov; Elena L Chernolovskaya
Journal:  FEBS Lett       Date:  2011-06-23       Impact factor: 4.124

4.  Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans.

Authors:  A Fire; S Xu; M K Montgomery; S A Kostas; S E Driver; C C Mello
Journal:  Nature       Date:  1998-02-19       Impact factor: 49.962

5.  Structure-based design of novel chemical modification of the 3'-overhang for optimization of short interfering RNA performance.

Authors:  Lexing Xu; Xin Wang; Hongwei He; Jinming Zhou; Xiaoyu Li; Hongtao Ma; Zelin Li; Yi Zeng; Rongguang Shao; Shan Cen; Yucheng Wang
Journal:  Biochemistry       Date:  2015-01-30       Impact factor: 3.162

6.  siRNAs modified with boron cluster and their physicochemical and biological characterization.

Authors:  Alina Kwiatkowska; Milena Sobczak; Barbara Mikolajczyk; Slawomir Janczak; Agnieszka B Olejniczak; Marek Sochacki; Zbigniew J Lesnikowski; Barbara Nawrot
Journal:  Bioconjug Chem       Date:  2013-05-29       Impact factor: 4.774

7.  Intracellular stability of 2'-OMe-4'-thioribonucleoside modified siRNA leads to long-term RNAi effect.

Authors:  Mayumi Takahashi; Chisato Nagai; Hiroto Hatakeyama; Noriaki Minakawa; Hideyoshi Harashima; Akira Matsuda
Journal:  Nucleic Acids Res       Date:  2012-03-12       Impact factor: 16.971

8.  Stereochemical bias introduced during RNA synthesis modulates the activity of phosphorothioate siRNAs.

Authors:  Hartmut Jahns; Martina Roos; Jochen Imig; Fabienne Baumann; Yuluan Wang; Ryan Gilmour; Jonathan Hall
Journal:  Nat Commun       Date:  2015-03-06       Impact factor: 14.919

9.  Development of modified siRNA molecules incorporating 5-fluoro-2'-deoxyuridine residues to enhance cytotoxicity.

Authors:  Shao-yu Wu; Tian-min Chen; William H Gmeiner; Edward Chu; John C Schmitz
Journal:  Nucleic Acids Res       Date:  2013-02-28       Impact factor: 16.971

10.  Silencing Myostatin Using Cholesterol-conjugated siRNAs Induces Muscle Growth.

Authors:  Tayeba Khan; Hans Weber; Jillian DiMuzio; Andrea Matter; Belma Dogdas; Tosha Shah; Anil Thankappan; Jyoti Disa; Vasant Jadhav; Laura Lubbers; Laura Sepp-Lorenzino; Walter R Strapps; Marija Tadin-Strapps
Journal:  Mol Ther Nucleic Acids       Date:  2016-08-02       Impact factor: 10.183
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  27 in total

1.  [Small interfering RNA-mediated programmed cell death-ligand 1 silencing in human glioma cells enhances human CD8+ T lymphocyte cytotoxicity in vitro].

Authors:  Zhen Wang; Wen Huang; Bohong Cen; Yuanyi Wei; Lumin Liao; Guoxian Li; Aimin Ji
Journal:  Nan Fang Yi Ke Da Xue Xue Bao       Date:  2018-07-30

2.  Optimization and characterization of position-selective labelling of RNA (PLOR) for diverse RNA and DNA sequences.

Authors:  Xiaoyu Zhang; Mengyang Li; Yu Liu
Journal:  RNA Biol       Date:  2020-04-19       Impact factor: 4.652

3.  Therapeutic Potential of OMe-PS-miR-29b1 for Treating Liver Fibrosis.

Authors:  Virender Kumar; Vinod Kumar; Jiangtao Luo; Ram I Mahato
Journal:  Mol Ther       Date:  2018-09-01       Impact factor: 11.454

Review 4.  Improving the therapeutic efficiency of noncoding RNAs in cancers using targeted drug delivery systems.

Authors:  Rami Alzhrani; Hashem O Alsaab; Alex Petrovici; Ketki Bhise; Kushal Vanamala; Samaresh Sau; Matthew J Krinock; Arun K Iyer
Journal:  Drug Discov Today       Date:  2019-11-20       Impact factor: 7.851

Review 5.  Biologics and their delivery systems: Trends in myocardial infarction.

Authors:  Matthew A Borrelli; Heth R Turnquist; Steven R Little
Journal:  Adv Drug Deliv Rev       Date:  2021-03-26       Impact factor: 17.873

Review 6.  Stimuli-responsive oligonucleotides in prodrug-based approaches for gene silencing.

Authors:  Françoise Debart; Christelle Dupouy; Jean-Jacques Vasseur
Journal:  Beilstein J Org Chem       Date:  2018-02-19       Impact factor: 2.883

Review 7.  The Complex Relationship between Diabetic Retinopathy and High-Mobility Group Box: A Review of Molecular Pathways and Therapeutic Strategies.

Authors:  Marcella Nebbioso; Alessandro Lambiase; Marta Armentano; Giosuè Tucciarone; Vincenza Bonfiglio; Rocco Plateroti; Ludovico Alisi
Journal:  Antioxidants (Basel)       Date:  2020-07-26

8.  TRAF6 Contributes to CFA-Induced Spinal Microglial Activation and Chronic Inflammatory Pain in Mice.

Authors:  Ying Lu; De-Li Cao; Ling-Jie Ma; Yong-Jing Gao
Journal:  Cell Mol Neurobiol       Date:  2021-03-10       Impact factor: 5.046

Review 9.  Triazole-Modified Nucleic Acids for the Application in Bioorganic and Medicinal Chemistry.

Authors:  Dagmara Baraniak; Jerzy Boryski
Journal:  Biomedicines       Date:  2021-05-31

10.  VEGF siRNA delivered by polycation liposome-encapsulated calcium phosphate nanoparticles for tumor angiogenesis inhibition in breast cancer.

Authors:  Jinliang Chen; Xiaoyi Sun; Rong Shao; Yichao Xu; Jianqing Gao; Wenquan Liang
Journal:  Int J Nanomedicine       Date:  2017-08-21
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