Literature DB >> 28378608

Predictive Value of Ex Vivo Chemosensitivity Assays for Individualized Cancer Chemotherapy: A Meta-Analysis.

Kristin Blom1, Peter Nygren2, Rolf Larsson1, Claes R Andersson1.   

Abstract

Current treatment strategies for chemotherapy of cancer patients were developed to benefit groups of patients with similar clinical characteristics. In practice, response is very heterogeneous between individual patients within these groups. Precision medicine can be viewed as the development toward a more fine-grained treatment stratification than what is currently in use. Cell-based drug sensitivity testing is one of several options for individualized cancer treatment available today, although it has not yet reached widespread clinical use. We present an up-to-date literature meta-analysis on the predictive value of ex vivo chemosensitivity assays for individualized cancer chemotherapy and discuss their current clinical value and possible future developments.

Entities:  

Keywords:  chemotherapy; ex vivo; individualized cancer therapy; tumor cell

Mesh：

Substances：

Year:  2017        PMID： 28378608     DOI： 10.1177/2472630316686297

Source DB:  PubMed          Journal:  SLAS Technol        ISSN： 2472-6303            Impact factor:   3.047


  8 in total

1.  Circulating tumour cell gene expression and chemosensitivity analyses: predictive accuracy for response to multidisciplinary treatment of patients with unresectable refractory recurrent rectal cancer or unresectable refractory colorectal cancer liver metastases.

Authors:  Andrew R Mackay; Marco Clementi; Stefano Guadagni; Francesco Masedu; Giammaria Fiorentini; Donatella Sarti; Caterina Fiorentini; Veronica Guadagni; Panagiotis Apostolou; Ioannis Papasotiriou; Panagiotis Parsonidis; Marco Valenti; Enrico Ricevuto; Gemma Bruera; Antonietta R Farina
Journal:  BMC Cancer       Date:  2022-06-16       Impact factor: 4.638

2.  Feasibility study of in vitro drug sensitivity assay of advanced non-small cell lung adenocarcinomas.

Authors:  Emoke Papp; Anita Steib; Elhusseiny Mm Abdelwahab; Judit Meggyes-Rapp; Laszlo Jakab; Gabor Smuk; Erzsebet Schlegl; Judit Moldvay; Veronika Sárosi; Judit E Pongracz
Journal:  BMJ Open Respir Res       Date:  2020-06

3.  Cisplatin treatment induced interleukin 6 and 8 production alters lung adenocarcinoma cell migration in an oncogenic mutation dependent manner.

Authors:  Edit Kiss; El Husseiny Mohamed Mahmud Abdelwahab; Anita Steib; Emoke Papp; Zsofia Torok; Laszlo Jakab; Gabor Smuk; Veronika Sarosi; Judit Erzsebet Pongracz
Journal:  Respir Res       Date:  2020-05-20

4.  Effect of oxaliplatin-based chemotherapy on chemosensitivity in patients with peritoneal metastasis from colorectal cancer treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: proof-of-concept study.

Authors:  A Prabhu; A Brandl; S Wakama; S Sako; H Ishibashi; A Mizumoto; N Takao; M Ichinose; S Motoi; Y Liu; Y Yonemura
Journal:  BJS Open       Date:  2021-03-05

Review 5.  Ex Vivo Culture Models to Indicate Therapy Response in Head and Neck Squamous Cell Carcinoma.

Authors:  Imke Demers; Johan Donkers; Bernd Kremer; Ernst Jan Speel
Journal:  Cells       Date:  2020-11-23       Impact factor: 6.600

6.  Ex Vivo Chemosensitivity Profiling of Acute Myeloid Leukemia and Its Correlation With Clinical Response and Outcome to Chemotherapy.

Authors:  Yi Zhang; Min Ji; Jin-Yan Zhao; Hua-Feng Wang; Chong-Wu Wang; Wei Li; Jing-Jing Ye; Fei Lu; Li-Hui Lin; Yan-Ting Gao; Jie Jin; Li Li; Chun-Yan Ji; Joan Ballesteros; Hong-Hu Zhu
Journal:  Front Oncol       Date:  2022-01-05       Impact factor: 6.244

7.  Chemosensitivity analysis and study of gene resistance on tumors and cancer stem cell isolates from patients with colorectal cancer.

Authors:  Elsa N Garza-Treviño; Herminia G Martínez-Rodríguez; Paulina Delgado-González; Orlando Solís-Coronado; Rocio Ortíz-Lopez; Adolfo Soto-Domínguez; Víctor M Treviño; Gerardo R Padilla-Rivas; Jose F Islas-Cisneros; Adriana G Quiroz-Reyes; Salvador L Said-Fernández
Journal:  Mol Med Rep       Date:  2021-08-13       Impact factor: 2.952

Review 8.  Precision Medicine Gains Momentum: Novel 3D Models and Stem Cell-Based Approaches in Head and Neck Cancer.

Authors:  Annette Affolter; Anne Lammert; Johann Kern; Claudia Scherl; Nicole Rotter
Journal:  Front Cell Dev Biol       Date:  2021-07-08
  8 in total

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