Literature DB >> 28377634

Penicillenols from a deep-sea fungus Aspergillus restrictus inhibit Candida albicans biofilm formation and hyphal growth.

Jie Wang1, Qi-Feng Yao1, Muhammad Amin1, Xu-Hua Nong1, Xiao-Yong Zhang1, Shu-Hua Qi1,2.   

Abstract

Penicillenols (A1, A2, B1, B2, C1 and C2) were isolated from Aspergillus restrictus DFFSCS006, and could differentially inhibit biofilm formation and eradicate pre-developed biofilms of Candida albicans. Their structure-bioactivity relationships suggested that the saturation of hydrocarbon chain at C-8, R-configuration of C-5 and trans-configuration of the double bond between C-5 and C-6 of pyrrolidine-2,4-dione unit were important for their anti-biofilm activities. Penicillenols A2 and B1 slowed the hyphal growth and suppressed the transcripts of hypha specific genes HWP1, ALS1, ALS3, ECE1 and SAP4. Moreover, penicillenols A2 and B1 were found to act synergistically with amphotericin B against C. albicans biofilm formation.

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Year:  2017        PMID： 28377634     DOI： 10.1038/ja.2017.45

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  20 in total

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Authors:  K J Livak; T D Schmittgen
Journal:  Methods       Date:  2001-12       Impact factor: 3.608

2.  Diverse deep-sea fungi from the South China Sea and their antimicrobial activity.

Authors:  Xiao-Yong Zhang; Yun Zhang; Xin-Ya Xu; Shu-Hua Qi
Journal:  Curr Microbiol       Date:  2013-06-05       Impact factor: 2.188

Review 3.  Growth of Candida albicans hyphae.

Authors:  Peter E Sudbery
Journal:  Nat Rev Microbiol       Date:  2011-08-16       Impact factor: 60.633

4.  Alkaloids from Xylariaceae sp., a marine-derived fungus.

Authors:  Xu-Hua Nong; Xiao-Yong Zhang; Xin-Ya Xu; Yun-Lin Sun; Shu-Hua Qi
Journal:  Nat Prod Commun       Date:  2014-04       Impact factor: 0.986

5.  Function of Candida albicans adhesin Hwp1 in biofilm formation.

Authors:  Clarissa J Nobile; Jeniel E Nett; David R Andes; Aaron P Mitchell
Journal:  Eukaryot Cell       Date:  2006-10

6.  Candida albicans Als3p is required for wild-type biofilm formation on silicone elastomer surfaces.

Authors:  Xiaomin Zhao; Karla J Daniels; Soon-Hwan Oh; Clayton B Green; Kathleen M Yeater; David R Soll; Lois L Hoyer
Journal:  Microbiology (Reading)       Date:  2006-08       Impact factor: 2.777

7.  Penicillenols from Penicillium sp. GQ-7, an endophytic fungus associated with Aegiceras corniculatum.

Authors:  Zhen-Jian Lin; Zhen-Yu Lu; Tian-Jiao Zhu; Yu-Chun Fang; Qian-Qun Gu; Wei-Ming Zhu
Journal:  Chem Pharm Bull (Tokyo)       Date:  2008-02       Impact factor: 1.645

8.  Inhibitory activity of thymol against the formation and viability of Candida albicans hyphae.

Authors:  P C Braga; M Alfieri; M Culici; M Dal Sasso
Journal:  Mycoses       Date:  2007-11       Impact factor: 4.377

9.  Plate method for detection of phospholipase activity in Candida albicans.

Authors:  M F Price; I D Wilkinson; L O Gentry
Journal:  Sabouraudia       Date:  1982-03

Review 10.  Marine natural products and their potential applications as anti-infective agents.

Authors:  Marwa Donia; Mark T Hamann
Journal:  Lancet Infect Dis       Date:  2003-06       Impact factor: 25.071
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  5 in total

1.  Phylogenetic analysis and antifouling potentials of culturable fungi in mangrove sediments from Techeng Isle, China.

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Journal:  World J Microbiol Biotechnol       Date:  2018-06-09       Impact factor: 3.312

Review 2.  The Biological and Chemical Diversity of Tetramic Acid Compounds from Marine-Derived Microorganisms.

Authors:  Minghua Jiang; Senhua Chen; Jing Li; Lan Liu
Journal:  Mar Drugs       Date:  2020-02-15       Impact factor: 5.118

3.  Antimicrobial and Antioxidant Polyketides from a Deep-Sea-Derived Fungus Aspergillus versicolor SH0105.

Authors:  Lu-Jia Yang; Xiao-Yue Peng; Ya-Hui Zhang; Zhi-Qing Liu; Xin Li; Yu-Cheng Gu; Chang-Lun Shao; Zhuang Han; Chang-Yun Wang
Journal:  Mar Drugs       Date:  2020-12-11       Impact factor: 5.118

4.  Synergistic antibacterial activity between penicillenols and antibiotics against methicillin-resistant Staphylococcus aureus.

Authors:  Shuihong Li; Qianqian Mou; Xinya Xu; Shuhua Qi; Polly H M Leung
Journal:  R Soc Open Sci       Date:  2018-05-30       Impact factor: 2.963

5.  Anti-Pathogenic Properties of the Combination of a T3SS Inhibitory Halogenated Pyrrolidone with C-30 Furanone.

Authors:  Nelly Araceli Aburto-Rodríguez; Naybi Muñoz-Cázares; Víctor Alberto Castro-Torres; Bertha González-Pedrajo; Miguel Díaz-Guerrero; Rodolfo García-Contreras; Héctor Quezada; Israel Castillo-Juárez; Mariano Martínez-Vázquez
Journal:  Molecules       Date:  2021-12-16       Impact factor: 4.411
  5 in total

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