Si-Jie Yuan1, Hai-Ting Xie, Zhong-Li Li. 1. Department of Respiratory, Zhujiang Hospital , Southern Medical University, Guangzhou 510282, China.E-mail: 269665687@qq.com.
Abstract
OBJECTIVE: To investigate the clinical significance of plasma levels of hypersensitive C-reactive protein (hs-CRP), fibriogen and D-dimmer (D-DI) in patients with connective tissue disease (CTD)-related interstitial lung disease (CTD-ILD). METHODS: Sixty-nine patients with interstitial lung disease admitted in Zhujiang Hospital between January, 2010 and April, 2016, including 29 with CTD-ILD and 40 with non-CTD-ILD were analyzed for plasma levels of hs-CRP, fibriogen and D-DI, with 25 healthy subjects as the control group. RESULTS: The plasma level of hs-CRP, fibriogen and D-DI in patients with CTD-ILD and non-CTD-ILD were all significantly higher than those in the control group. The patients with CTD-ILD had a significantly higher hs-CRP level than those with non-CTD-ILD, but the levels of fibriogen and D-DI were comparable between the two groups. Correlation analysis indicated that Hs-CRP level was positively correlated with the levels of D-DI (r=0.539, P<0.01) and fibrinogen (r=0.534, P<0.01). CONCLUSION: Hs-CRP, fibriogen and D-DI levels show an important value in clinical diagnosis of CTD, and an obvious elevation of hs-CRP is correlated with the CTD.
OBJECTIVE: To investigate the clinical significance of plasma levels of hypersensitiveC-reactive protein (hs-CRP), fibriogen and D-dimmer (D-DI) in patients with connective tissue disease (CTD)-related interstitial lung disease (CTD-ILD). METHODS: Sixty-nine patients with interstitial lung disease admitted in Zhujiang Hospital between January, 2010 and April, 2016, including 29 with CTD-ILD and 40 with non-CTD-ILD were analyzed for plasma levels of hs-CRP, fibriogen and D-DI, with 25 healthy subjects as the control group. RESULTS: The plasma level of hs-CRP, fibriogen and D-DI in patients with CTD-ILD and non-CTD-ILD were all significantly higher than those in the control group. The patients with CTD-ILD had a significantly higher hs-CRP level than those with non-CTD-ILD, but the levels of fibriogen and D-DI were comparable between the two groups. Correlation analysis indicated that Hs-CRP level was positively correlated with the levels of D-DI (r=0.539, P<0.01) and fibrinogen (r=0.534, P<0.01). CONCLUSION: Hs-CRP, fibriogen and D-DI levels show an important value in clinical diagnosis of CTD, and an obvious elevation of hs-CRP is correlated with the CTD.
Authors: Dominic Snijders; Margreet Schoorl; Marianne Schoorl; Piet C Bartels; Tjip S van der Werf; Wim G Boersma Journal: Eur J Intern Med Date: 2011-11-21 Impact factor: 4.487
Authors: Desa Nastasijević Borovac; Tatjana Radjenović Petković; Tatjana Pejčić; Ivana Stanković; Irena Janković; Zorica Ćirić; Milan Rančić Journal: Med Glas (Zenica) Date: 2014-02
Authors: Meindert Johannes Crop; Claire Siemes; Paul Berendes; Frans van der Straaten; Sten Willemsen; Mark-David Levin Journal: Eur J Haematol Date: 2013-11-22 Impact factor: 2.997