Literature DB >> 28377012

Mental Disorders in People Affected by Thalidomide.

Alexander Niecke1, Klaus Peters, Christina Samel, Kristin Forster, Markus Lüngen, Holger Pfaff, Christian Albus.   

Abstract

BACKGROUND: More than 50 years after the withdrawal of thalidomide from the market, subsequent orthopedic damages and psychosocial impairments dominate the complaints of thalidomide-affected individuals. The aim of the study was to determine the prevalence of mental disorders in this group.
METHODS: A total of 193 thalidomide-affected individuals from North Rhine-Westphalia (mean age 50.5 years, 56.5% women) underwent personal and comprehensive psychodiagnostic testing, which was based on the Structured Clinical Interview for DSM-IV disorders (SCID-I & SCID-II) and self-reporting questionnaires.
RESULTS: Overall, the four-week prevalence of mental disorders was 47.2%. Multiple mental disorders were present in 45.1% among the 91 participants with diagnosed mental disorders. The most frequent diagnoses were unipolar depressive disorders (16.5%), somatoform disorders (14.0%), phobic disorders (12.4%), and alcohol-related disorders (6.2%). Immediate mental health care was indicated in 80.2% of participants with current mental disorders, but only 29.7% had used some form of psychosocial treatment in the 12 months preceding the study.
CONCLUSION: Mental disorders occur approximately twice as often (relative risk [RR]: 1.77; 95% confidence interval [1.49; 2.10]) in thalidomide-affected individuals as in the age-matched German population. Together with a very low rate of utilization of mental health care, this finding implies an underuse of psychosocial healthcare. The development of specialized psychosocial treatment services may remove barriers that impede access to the healthcare system.

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Year:  2017        PMID: 28377012      PMCID: PMC5382242          DOI: 10.3238/arztebl.2017.0168

Source DB:  PubMed          Journal:  Dtsch Arztebl Int        ISSN: 1866-0452            Impact factor:   5.594


  19 in total

1.  Thalidomide embryopathy: Follow-up of cases born between 1959 and 2010.

Authors:  Thayne Woycinck Kowalski; Maria Teresa Vieira Sanseverino; Lavinia Schuler-Faccini; Fernanda Sales Luiz Vianna
Journal:  Birth Defects Res A Clin Mol Teratol       Date:  2015-06-04

2.  Thalidomide: was the tragedy preventable?

Authors:  A Dally
Journal:  Lancet       Date:  1998-04-18       Impact factor: 79.321

Review 3.  A short history of thalidomide embryopathy.

Authors:  W Lenz
Journal:  Teratology       Date:  1988-09

4.  Thalidomide and its sequelae.

Authors:  Michael Emanuel; Michael Rawlins; Gordon Duff; Alasdair Breckenridge
Journal:  Lancet       Date:  2012-09-01       Impact factor: 79.321

Review 5.  Prenatal factors associated with autism spectrum disorder (ASD).

Authors:  A Ornoy; L Weinstein-Fudim; Z Ergaz
Journal:  Reprod Toxicol       Date:  2015-05-27       Impact factor: 3.143

6.  Thalidomide: the tragedy of birth defects and the effective treatment of disease.

Authors:  James H Kim; Anthony R Scialli
Journal:  Toxicol Sci       Date:  2011-04-19       Impact factor: 4.849

7.  Psychological and mental health problems in patients with thalidomide embryopathy in Japan.

Authors:  Koubun Imai; Toshiharu Iida; Maki Yamamoto; Kensuke Komatsu; Yuko Nukui; Atsuto Yoshizawa
Journal:  Psychiatry Clin Neurosci       Date:  2014-02-18       Impact factor: 5.188

Review 8.  Thalidomide.

Authors:  Michael E Franks; Gordon R Macpherson; William D Figg
Journal:  Lancet       Date:  2004-05-29       Impact factor: 79.321

9.  Increased 12-month prevalence rates of mental disorders in patients with chronic somatic diseases.

Authors:  Martin Härter; Harald Baumeister; Katrin Reuter; Frank Jacobi; Michael Höfler; Jürgen Bengel; Hans-Ulrich Wittchen
Journal:  Psychother Psychosom       Date:  2007       Impact factor: 17.659

10.  Twelve-month prevalence, comorbidity and correlates of mental disorders in Germany: the Mental Health Module of the German Health Interview and Examination Survey for Adults (DEGS1-MH).

Authors:  Frank Jacobi; Michael Höfler; Jens Siegert; Simon Mack; Anja Gerschler; Lucie Scholl; Markus A Busch; Ulfert Hapke; Ulrike Maske; Ingeburg Seiffert; Wolfgang Gaebel; Wolfgang Maier; Michael Wagner; Jürgen Zielasek; Hans-Ulrich Wittchen
Journal:  Int J Methods Psychiatr Res       Date:  2014-04-11       Impact factor: 4.035

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  6 in total

1.  Additional Points Need to Be Raised.

Authors:  Frank P Meyer
Journal:  Dtsch Arztebl Int       Date:  2017-07-10       Impact factor: 5.594

2.  In Reply.

Authors:  Alexander Niecke
Journal:  Dtsch Arztebl Int       Date:  2017-07-10       Impact factor: 5.594

3.  Life situation of women impaired by Thalidomide embryopathy in North Rhine-Westphalia - a comparative analysis of a recent cross-sectional study with earlier data.

Authors:  Christina Samel; Christian Albus; Irmgard Nippert; Alexander Niecke; Markus Lüngen; Holger Pfaff; Klaus M Peters
Journal:  BMC Womens Health       Date:  2019-04-03       Impact factor: 2.809

4.  Addictive Use of Smartphones and Mental Disorders in University Students.

Authors:  Seyyed Salman Alavi; Maryam Ghanizadeh; Malihe Farahani; Fereshteh Jannatifard; Sudeh Esmaili Alamuti; Mohammad Reza Mohammadi
Journal:  Iran J Psychiatry       Date:  2020-04

5.  Psychological Factors Including Demographic Features, Mental Illnesses, and Personality Disorders as Predictors in Internet Addiction Disorder.

Authors:  Malihe Farahani; Seyyed Salman Alavi; Mahmood Mirzamani Bafghi; Sudeh Esmaili Alamuti; Zohreh Taghavi; Mohammadreza Mohammadi
Journal:  Iran J Psychiatry       Date:  2018-04

6.  Quality of life and pain in patients with thalidomide embryopathy in Japan.

Authors:  Koubun Imai; Hanae Sone; Ken Otomo; Yuki Nakano; Fumihiko Hinoshita
Journal:  Mol Genet Genomic Med       Date:  2020-09-06       Impact factor: 2.183

  6 in total

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