Literature DB >> 2837683

New quinoxalinediones show potent antagonism of quisqualate responses in cultured mouse cortical neurons.

J Drejer1, T Honoré.   

Abstract

Two new quinoxalines, DNQX (6,7-dinitro-quinoxaline-2,3-dion = FG 9041) and CNQX (6-nitro-7-cyano-quinoxaline-2,3-dion = FG 9065), were tested as antagonists of excitatory amino acid responses in cultured neurons and brain slices. DNQX and CNQX showed potent competitive antagonism of quisqualate and kainate induced [3H]GABA release from cultured mouse cortical neurons with weaker effects on NMDA responses (Schild values for DNQX were 6.2, 5.9 and 5.4, respectively). Also in a model of excitatory amino acid induced 22Na efflux from striatal slices DNQX blocked responses to quisqualate and kainate more effectively than responses to NMDA.

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Year:  1988        PMID： 2837683     DOI： 10.1016/0304-3940(88)90153-x

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  16 in total

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Authors:  R Miles
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4.  Effects of new non-N-methyl-D-aspartate antagonists on synaptic transmission in the in vitro rat hippocampus.

Authors:  M Andreasen; J D Lambert; M S Jensen
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5.  Novel expression mechanism for synaptic potentiation: alignment of presynaptic release site and postsynaptic receptor.

Authors:  X Xie; J S Liaw; M Baudry; T W Berger
Journal:  Proc Natl Acad Sci U S A       Date:  1997-06-24       Impact factor: 11.205

6.  Focal stimulation of specific pathways in the rat hippocampus causes a reduction in radioligand binding to the haloperidol-sensitive sigma receptor.

Authors:  M A Connor; C Chavkin
Journal:  Exp Brain Res       Date:  1991       Impact factor: 1.972

7.  Paroxysmal inhibitory potentials mediated by GABAB receptors in partially disinhibited rat hippocampal slice cultures.

Authors:  M Scanziani; B H Gähwiler; S M Thompson
Journal:  J Physiol       Date:  1991-12       Impact factor: 5.182

8.  Characterization of two central AMPA-preferring receptors having distinct location, function and pharmacology.

Authors:  A Pittaluga; S Thellung; G Maura; M Raiteri
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Review 9.  AMPA receptors as a molecular target in epilepsy therapy.

Authors:  M A Rogawski
Journal:  Acta Neurol Scand Suppl       Date:  2013

10.  The effect of omega-conotoxin GVIA on synaptic transmission within the nucleus accumbens and hippocampus of the rat in vitro.

Authors:  A L Horne; J A Kemp
Journal:  Br J Pharmacol       Date:  1991-07       Impact factor: 8.739
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