Patrícia Sanches1, Elaine Keiko Fujisao2, Aline M S Braga2, Nathalia Raquel Cristaldo2, Roberto Dos Reis1, Seizo Yamashita3, Luiz Eduardo Betting4. 1. Departamento de Neurologia, Psicologia e Psiquiatria, Faculdade de Medicina de Botucatu - UNESP - Univ Estadual Paulista, Brazil; Departamento de Doenças Tropicais e Diagnóstico por Imagem, Faculdade de Medicina de Botucatu - UNESP - Univ Estadual Paulista, Brazil. 2. Departamento de Neurologia, Psicologia e Psiquiatria, Faculdade de Medicina de Botucatu - UNESP - Univ Estadual Paulista, Brazil. 3. Departamento de Doenças Tropicais e Diagnóstico por Imagem, Faculdade de Medicina de Botucatu - UNESP - Univ Estadual Paulista, Brazil. 4. Departamento de Neurologia, Psicologia e Psiquiatria, Faculdade de Medicina de Botucatu - UNESP - Univ Estadual Paulista, Brazil. Electronic address: betting@fmb.unesp.br.
Abstract
PURPOSE: Quantitative techniques of diffusion analysis allow for an in-vivo investigation of the physiopathology of epilepsies. The objective of this study was to evaluate the variation of the main diffusion parameters and explore differences between two methodologies of voxel-wise analysis comparing a group of patients with mesial temporal lobe epilepsy (MTLE) with controls. METHODS: 24 patients with a diagnosis of MTLE were selected. All patients and a control group of 36 individuals were submitted to 3T magnetic resonance imaging. Diffusion parameters were obtained from the raw images. Based on the tensors, a customized template was created, and images were registered into standard space. Voxel-based comparisons between patients and controls was performed by whole brain voxel-wise analysis and tract-based spatial statistics (TBSS). Tract-specific analysis (TSA) was performed in the mostly damaged fasciculi. RESULTS: 10 patients presented with right hippocampal sclerosis (HS), 11 with left HS and 3 with bilateral HS with left predominance. Whole brain voxel-wise analysis showed abnormalities mainly localized in the temporal lobes (total volume of 3859mm3). TBSS showed more widespread abnormalities (21931mm3). TSA pointed to abnormalities situated essentially in the temporal stem topography. Fractional anisotropy (FA) and radial diffusivity (RD) were the parameters that showed more abnormalities. CONCLUSION: Whole brain voxel-wise analysis was more restricted than TBSS. The methods were complementary stressing the significance of the findings. The abnormalities were more frequently observed in FA and RD indicating the need for using several diffusion parameters for the investigation of patients with MTLE.
PURPOSE: Quantitative techniques of diffusion analysis allow for an in-vivo investigation of the physiopathology of epilepsies. The objective of this study was to evaluate the variation of the main diffusion parameters and explore differences between two methodologies of voxel-wise analysis comparing a group of patients with mesial temporal lobe epilepsy (MTLE) with controls. METHODS: 24 patients with a diagnosis of MTLE were selected. All patients and a control group of 36 individuals were submitted to 3T magnetic resonance imaging. Diffusion parameters were obtained from the raw images. Based on the tensors, a customized template was created, and images were registered into standard space. Voxel-based comparisons between patients and controls was performed by whole brain voxel-wise analysis and tract-based spatial statistics (TBSS). Tract-specific analysis (TSA) was performed in the mostly damaged fasciculi. RESULTS: 10 patients presented with right hippocampal sclerosis (HS), 11 with left HS and 3 with bilateral HS with left predominance. Whole brain voxel-wise analysis showed abnormalities mainly localized in the temporal lobes (total volume of 3859mm3). TBSS showed more widespread abnormalities (21931mm3). TSA pointed to abnormalities situated essentially in the temporal stem topography. Fractional anisotropy (FA) and radial diffusivity (RD) were the parameters that showed more abnormalities. CONCLUSION: Whole brain voxel-wise analysis was more restricted than TBSS. The methods were complementary stressing the significance of the findings. The abnormalities were more frequently observed in FA and RD indicating the need for using several diffusion parameters for the investigation of patients with MTLE.
Authors: Joshua Fisher; Mahdi Alizadeh; Devon Middleton; Caio M Matias; M J Mulcahey; Christina Calhoun-Thielen; Feroze B Mohamed; Laura Krisa Journal: Top Spinal Cord Inj Rehabil Date: 2021-06-04
Authors: Irena Buksakowska; Nikoletta Szabó; Lukáš Martinkovič; Péter Faragó; András Király; Jiří Vrána; Zsigmond Tamás Kincses; Jan Meluzín; Vlastimil Šulc; Martin Kynčl; Miloslav Roček; Michal Tichý; František Charvát; Daniel Hořínek; Petr Marusič Journal: Front Neurol Date: 2019-10-01 Impact factor: 4.003