Literature DB >> 2837436

Binding of [125I]corticotropin releasing factor to blood immunocytes and its reduction in Alzheimer's disease.

V K Singh1, H H Fudenberg.   

Abstract

The binding of [125I]iodine-labelled corticotropin releasing factor (CRF) was studied using peripheral blood lymphocytes from normal donors and Alzheimer's disease (AD) patients. The high affinity binding of [125I]CRF was found in the membranes of various immunocytes. Monocytes and T cells displayed binding which was several times greater than the binding of brain (cortical) cells. The immunocyte CRF binding was significantly (P less than 0.001) lower in 14 out of 18 (78%) AD patients relative to non-AD controls, suggesting the association of CRF in the pathology of AD. Our data demonstrate that blood immunocytes can be used to analyze deficiency of neurohormone sites in neuropsychiatric diseases, e.g., AD.

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Year:  1988        PMID： 2837436     DOI： 10.1016/0165-2478(88)90061-2

Source DB:  PubMed          Journal:  Immunol Lett        ISSN： 0165-2478            Impact factor:   3.685


  13 in total

1.  Corticotropin Releasing Factor (CRF) activation of NF-kappaB-directed transcription in leukocytes.

Authors:  Eric M Smith; Mike Gregg; Farhad Hashemi; Liesl Schott; Thomas K Hughes
Journal:  Cell Mol Neurobiol       Date:  2006-04-22       Impact factor: 5.046

2.  Neuropeptides as signal molecules in common with leukocytes and the hypothalamic-pituitary-adrenal axis.

Authors:  Eric M Smith
Journal:  Brain Behav Immun       Date:  2007-09-27       Impact factor: 7.217

3.  Plasma cytokine response to surgical stress in schizophrenic patients.

Authors:  A Kudoh; T Sakai; H Ishihara; A Matsuki
Journal:  Clin Exp Immunol       Date:  2001-07       Impact factor: 4.330

4.  TRH receptor on immune cells: in vitro and in vivo stimulation of human lymphocyte and rat splenocyte DNA synthesis by TRH.

Authors:  S Raiden; E Polack; V Nahmod; M Labeur; F Holsboer; E Arzt
Journal:  J Clin Immunol       Date:  1995-09       Impact factor: 8.317

5.  Corticotropin-releasing hormone augments proinflammatory cytokine production from macrophages in vitro and in lipopolysaccharide-induced endotoxin shock in mice.

Authors:  Sofia Agelaki; Christos Tsatsanis; Achille Gravanis; Andrew N Margioris
Journal:  Infect Immun       Date:  2002-11       Impact factor: 3.441

6.  Evidence for CRHR1 in multiple sclerosis using supervised machine learning and meta-analysis in 12,566 individuals.

Authors:  Farren B S Briggs; Selena E Bartlett; Benjamin A Goldstein; Joanne Wang; Jacob L McCauley; Rebecca L Zuvich; Philip L De Jager; John D Rioux; Adrian J Ivinson; Alastair Compston; David A Hafler; Stephen L Hauser; Jorge R Oksenberg; Stephen J Sawcer; Margaret A Pericak-Vance; Jonathan L Haines; Lisa F Barcellos
Journal:  Hum Mol Genet       Date:  2010-08-10       Impact factor: 6.150

7.  Divergent effects of corticotropin releasing hormone on endothelial cell nitric oxide synthase are associated with different expression of CRH type 1 and 2 receptors.

Authors:  G Cantarella; L Lempereur; G Lombardo; A Chiarenza; C Pafumi; G Zappalà; R Bernardini
Journal:  Br J Pharmacol       Date:  2001-10       Impact factor: 8.739

8.  Local secretion of corticotropin-releasing hormone in the joints of Lewis rats with inflammatory arthritis.

Authors:  L J Crofford; H Sano; K Karalis; E L Webster; E A Goldmuntz; G P Chrousos; R L Wilder
Journal:  J Clin Invest       Date:  1992-12       Impact factor: 14.808

9.  Studies of neuroimmune markers in Alzheimer's disease.

Authors:  V K Singh
Journal:  Mol Neurobiol       Date:  1994 Aug-Dec       Impact factor: 5.590

Review 10.  Neuroendocrine-immune disequilibrium and endometriosis: an interdisciplinary approach.

Authors:  Nadja Tariverdian; Theoharis C Theoharides; Friederike Siedentopf; Gabriela Gutiérrez; Udo Jeschke; Gabriel A Rabinovich; Sandra M Blois; Petra C Arck
Journal:  Semin Immunopathol       Date:  2007-06       Impact factor: 9.623
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