Mehmet Öztürk1, İsmail Akdulum2, Nurullah Dağ2, Ahmet Sığırcı2, Serdal Güngör3, Sezai Yılmaz4. 1. Department of Pediatric Radiology, Diyarbakır Children's Hospital, 21100, Diyarbakir, Turkey. drmehmet2121@gmail.com. 2. Department of Pediatric Radiology, Inonu University School of Medicine, 44100, Malatya, Turkey. 3. Department of Pediatric Neurology, Inonu University School of Medicine, 44100, Malatya, Turkey. 4. Department of General Surgery, Inonu University School of Medicine, 44100, Malatya, Turkey.
Abstract
OBJECTIVE: To analyze the magnetic resonance imaging findings in children diagnosed with neurologic complications after liver transplantation (LT). MATERIALS AND METHODS: A total of 39 patients diagnosed with neurologic complications following LT between 2010 and 2016. Neuroradiologic imaging was performed using cranial magnetic resonance imaging (MRI). Descriptive statistics regarding age, gender, type of complication, diagnostic and therapeutic modalities were calculated and presented as number and percentage. RESULTS: Our series consisted of 18 girls and 21 boys. Cryptogenic hepatitis (n = 13, 32%), metabolic diseases (Wilson's disease, tyrosinemia and glycogen storage disease) (n = 7, 18%) and fulminant toxic hepatitis (n = 4, 11%) constitute the most frequent indications for LT. The indications for neuroradiological imaging were convulsion and alteration of mental status. CONCLUSION: These central nervous system complications may present in a variable spectrum and convulsions and altered mental state were the most frequent clinical pictures. Imaging studies were normal in approximately one-third of cases; the most frequent pathologic findings were diffuse cerebral edema, atrophy, and PRES. Clinical history, careful examination and integrated analysis of radiologic data as well as close collaboration and multidisciplinary approach are of utmost importance for establishing the diagnosis rapidly and accurately.
OBJECTIVE: To analyze the magnetic resonance imaging findings in children diagnosed with neurologic complications after liver transplantation (LT). MATERIALS AND METHODS: A total of 39 patients diagnosed with neurologic complications following LT between 2010 and 2016. Neuroradiologic imaging was performed using cranial magnetic resonance imaging (MRI). Descriptive statistics regarding age, gender, type of complication, diagnostic and therapeutic modalities were calculated and presented as number and percentage. RESULTS: Our series consisted of 18 girls and 21 boys. Cryptogenic hepatitis (n = 13, 32%), metabolic diseases (Wilson's disease, tyrosinemia and glycogen storage disease) (n = 7, 18%) and fulminant toxic hepatitis (n = 4, 11%) constitute the most frequent indications for LT. The indications for neuroradiological imaging were convulsion and alteration of mental status. CONCLUSION: These central nervous system complications may present in a variable spectrum and convulsions and altered mental state were the most frequent clinical pictures. Imaging studies were normal in approximately one-third of cases; the most frequent pathologic findings were diffuse cerebral edema, atrophy, and PRES. Clinical history, careful examination and integrated analysis of radiologic data as well as close collaboration and multidisciplinary approach are of utmost importance for establishing the diagnosis rapidly and accurately.
Entities:
Keywords:
Children; Complication; Liver; Magnetic resonance imaging; Neurologic; Transplantation
Authors: G Ardizzone; A Arrigo; M M Schellino; C Stratta; S Valzan; S Skurzak; P Andruetto; A Panio; M A Ballaris; B Lavezzo; M Salizzoni; E Cerutti Journal: Transplant Proc Date: 2006-04 Impact factor: 1.066
Authors: C A Bonham; E A Dominguez; M B Fukui; D L Paterson; G A Pankey; M M Wagener; J J Fung; N Singh Journal: Transplantation Date: 1998-12-27 Impact factor: 4.939
Authors: F Menegaux; E B Keeffe; B T Andrews; H Egawa; H Monge; W Concepcion; S K So; C O Esquivel Journal: Transplantation Date: 1994-08-27 Impact factor: 4.939
Authors: Alicia M Alcamo; Robert S B Clark; Alicia K Au; Sajel Kantawala; Eric J Yablonsky; Rakesh Sindhi; George V Mazariegos; Rajesh K Aneja; Christopher M Horvat Journal: Pediatr Crit Care Med Date: 2020-09 Impact factor: 3.971