Wengang Ding1, Wanying Li1, Xianzhang Zeng1, Jinying Li1, Jingjing Jiang1, Changchun Guo1, Wenzhi Li2. 1. Department of Anesthesiology, The Second Affiliated Hospital of Harbin Medical University, 246, Xuefu Road, Harbin, Heilongjiang, 150086, China. 2. Department of Anesthesiology, The Second Affiliated Hospital of Harbin Medical University, 246, Xuefu Road, Harbin, Heilongjiang, 150086, China. liwanyingde@sina.com.
Abstract
OBJECTIVES:Transversus abdominis plane (TAP) block is an analgesic technique. Adding dexmedetomidine can enhance regional anesthesia. This study's aim was to evaluate whether dexmedetomidine prolonged analgesic time of TAP block after gastrectomy. METHODS:Patients scheduled for gastrectomy were randomly assigned to receive a TAP block with saline (group S), ropivacaine (group R), or ropivacaine and dexmedetomidine (group RD). Visual analogue scale (VAS) scores, postoperative nausea and vomiting (PONV) scores, sedation scores, tramadol consumption, ropivacaine concentration, and Quality of Recovery Questionnaire 40 (QoR-40) were recorded. RESULTS: Patients in group R and group RD had lower VAS scores 2, 4, 12, and 24 h after surgery compared with group S (P < 0.05). PONV scores were lower in group R and group RD compared with group S after 2, 12, 24, and 36 h (P < 0.05). Patients in group R and group RD required less tramadol and had better QoR-40 scores than those in group S (P < 0.05). The aforementioned variables and ropivacaine concentrations did not differ between group R and group RD (P > 0.05). Sedation scores were similar between three groups (P > 0.05). CONCLUSIONS:TAP block can provide analgesia and improve the quality of recovery. Adding dexmedetomidine does not significantly improve the quality or duration of TAP block.
RCT Entities:
OBJECTIVES: Transversus abdominis plane (TAP) block is an analgesic technique. Adding dexmedetomidine can enhance regional anesthesia. This study's aim was to evaluate whether dexmedetomidine prolonged analgesic time of TAP block after gastrectomy. METHODS:Patients scheduled for gastrectomy were randomly assigned to receive a TAP block with saline (group S), ropivacaine (group R), or ropivacaine and dexmedetomidine (group RD). Visual analogue scale (VAS) scores, postoperative nausea and vomiting (PONV) scores, sedation scores, tramadol consumption, ropivacaine concentration, and Quality of Recovery Questionnaire 40 (QoR-40) were recorded. RESULTS:Patients in group R and group RD had lower VAS scores 2, 4, 12, and 24 h after surgery compared with group S (P < 0.05). PONV scores were lower in group R and group RD compared with group S after 2, 12, 24, and 36 h (P < 0.05). Patients in group R and group RD required less tramadol and had better QoR-40 scores than those in group S (P < 0.05). The aforementioned variables and ropivacaine concentrations did not differ between group R and group RD (P > 0.05). Sedation scores were similar between three groups (P > 0.05). CONCLUSIONS: TAP block can provide analgesia and improve the quality of recovery. Adding dexmedetomidine does not significantly improve the quality or duration of TAP block.
Authors: D Latzke; P Marhofer; S C Kettner; K Koppatz; K Turnheim; E Lackner; R Sauermann; M Müller; M Zeitlinger Journal: Eur J Clin Pharmacol Date: 2011-10-27 Impact factor: 2.953
Authors: Marcia A Corvetto; Ghislaine C Echevarría; Natalia De La Fuente; Loreto Mosqueira; Sandra Solari; Fernando R Altermatt Journal: Reg Anesth Pain Med Date: 2012 Nov-Dec Impact factor: 6.288