Hatice Harmanci1, Feryal Çam Çelikel2, İlker Etikan3. 1. Clinic of Psychiatry, Mehmet Akif İnan Training and Research Hospital, Şanlıurfa, Turkey. 2. Clinic of Psychiatry, Baltalimanı Bone Diseases Training and Research Hospital, İstanbul, Turkey. 3. Department of Biostatistics, Yakın Doğu University School of Medicine, Nicosia, Turkish Republic of Northern Cyprus.
Abstract
INTRODUCTION: The co-occurrence of attention deficit hyperactivity disorder (ADHD) in affective disorder patients is considerably high. The aims of the present study were to search for the frequency and impact of ADHD co-occurrence on the clinical features of affective disorders and to examine the relationship between the dominant affective temperaments and ADHD. METHODS: In total, 100 patients with bipolar disorder (BD), 100 patients with major depressive disorder (MDD), and 100 healthy controls (HC) were included. All diagnoses were assigned according to DSM-IV-TR criteria. The Adult Attention Deficit and Hyperactivity Self-Report Scale (ASRS); Wender Utah Rating Scale (WURS); and Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Autoquestionnaire (TEMPS-A) were applied to all participants. RESULTS: The percentage of BD patients meeting the criteria for a diagnosis of current ADHD was 48% compared with the percentage of MDD patients and HCC subjects, i.e., 25% and 12%, respectively. ADHD was significantly more frequent in bipolar adults than in not only HC but also depressive patients. In the BD group, patients with a comorbid ADHD diagnosis had significantly more suicidal history than those without ADHD. The scores of the temperament traits, namely depressive, cyclothymic, irritable, and anxious, were significantly higher in subjects with ADHD in all groups, including in HC. CONCLUSION: The most important findings of the present study were the observations that (1) the frequency of ADHD is considerably high among bipolar patients; (2) the frequency of suicide attempts is high in the bipolar patient group with comorbid ADHD; and (3) depressive, cyclothymic, irritable, and anxious temperaments are significantly associated with ADHD comorbidity in bipolar and depressive patients as well as in HC. The high comorbidity and chronic course of ADHD and its possible negative influence on the course of both disorders increase the importance of screening for adult ADHD.
INTRODUCTION: The co-occurrence of attention deficit hyperactivity disorder (ADHD) in affective disorderpatients is considerably high. The aims of the present study were to search for the frequency and impact of ADHD co-occurrence on the clinical features of affective disorders and to examine the relationship between the dominant affective temperaments and ADHD. METHODS: In total, 100 patients with bipolar disorder (BD), 100 patients with major depressive disorder (MDD), and 100 healthy controls (HC) were included. All diagnoses were assigned according to DSM-IV-TR criteria. The Adult Attention Deficit and Hyperactivity Self-Report Scale (ASRS); Wender Utah Rating Scale (WURS); and Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Autoquestionnaire (TEMPS-A) were applied to all participants. RESULTS: The percentage of BD patients meeting the criteria for a diagnosis of current ADHD was 48% compared with the percentage of MDDpatients and HCC subjects, i.e., 25% and 12%, respectively. ADHD was significantly more frequent in bipolar adults than in not only HC but also depressivepatients. In the BD group, patients with a comorbid ADHD diagnosis had significantly more suicidal history than those without ADHD. The scores of the temperament traits, namely depressive, cyclothymic, irritable, and anxious, were significantly higher in subjects with ADHD in all groups, including in HC. CONCLUSION: The most important findings of the present study were the observations that (1) the frequency of ADHD is considerably high among bipolarpatients; (2) the frequency of suicide attempts is high in the bipolarpatient group with comorbid ADHD; and (3) depressive, cyclothymic, irritable, and anxious temperaments are significantly associated with ADHD comorbidity in bipolar and depressivepatients as well as in HC. The high comorbidity and chronic course of ADHD and its possible negative influence on the course of both disorders increase the importance of screening for adult ADHD.
Authors: J Biederman; S V Faraone; T Spencer; T Wilens; D Norman; K A Lapey; E Mick; B K Lehman; A Doyle Journal: Am J Psychiatry Date: 1993-12 Impact factor: 18.112
Authors: Sally I Sharp; Andrew McQuillin; Michael Marks; Stephen P Hunt; S Clare Stanford; Greg J Lydall; Marsha Y Morgan; Philip Asherson; David Curtis; Hugh M D Gurling Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2014-05-09 Impact factor: 3.568
Authors: Louise Öhlund; Michael Ott; Robert Lundqvist; Mikael Sandlund; Ellinor Salander Renberg; Ursula Werneke Journal: Ther Adv Psychopharmacol Date: 2020-08-06