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Literature DB >> 28372826

Titrating Tipsy Targets: The Neurobiology of Low-Dose Alcohol.

Abstract

Limited attention has been given to our understanding of how the brain responds to low-dose alcohol (ethanol) and what molecular and cellular targets mediate these effects. Even at concentrations lower than 10mM (0.046 g% blood alcohol concentration, BAC), below the legal driving limit in the USA (BAC 0.08 g%), alcohol impacts brain function and behavior. Understanding what molecular and cellular targets mediate the initial effects of alcohol and subsequent neuroplasticity could provide a better understanding of vulnerability or resilience to developing alcohol use disorders. We review here what is known about the neurobiology of low-dose alcohol, provide insights into potential molecular targets, and discuss future directions and challenges in further defining targets of low-dose alcohol at the molecular, cellular, and circuitry levels. Published by Elsevier Ltd.

Entities: CellLine Chemical Disease Gene Mutation Species

Keywords: alcohol; ethanol; intoxication; low-dose; molecular targets; neurobiology

Mesh：

Substances：
Ethanol

Year: 2017 PMID： 28372826 PMCID： PMC5597438 DOI： 10.1016/j.tips.2017.03.002

Source DB: PubMed Journal: Trends Pharmacol Sci ISSN： 0165-6147 Impact factor: 14.819

82 in total

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Journal: Nat Commun Date: 2013 Impact factor: 14.919

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24 in total

Review 1. Alcohol use disorder and sleep disturbances: a feed-forward allostatic framework.

Authors: George F Koob; Ian M Colrain
Journal: Neuropsychopharmacology Date: 2019-06-24 Impact factor: 7.853

Review 2. Low Vs. High Alcohol: Central Benefits Vs. Detriments.

Authors: Yousef Tizabi; Bruk Getachew; Clifford L Ferguson; Antonei B Csoka; Karl M Thompson; Alejandra Gomez-Paz; Jana Ruda-Kucerova; Robert E Taylor
Journal: Neurotox Res Date: 2018-01-04 Impact factor: 3.911

3. Acute alcohol exposure dose-dependently alleviates social avoidance in adolescent mice and inhibits social investigation in adult mice.

Authors: Joel S Raymond; Bianca B Wilson; Oliver Tan; Anand Gururajan; Michael T Bowen
Journal: Psychopharmacology (Berl) Date: 2019-07-25 Impact factor: 4.530

Review 4. Glycine receptors and glycine transporters: targets for novel analgesics?

Authors: Hanns Ulrich Zeilhofer; Mario A Acuña; Jacinthe Gingras; Gonzalo E Yévenes
Journal: Cell Mol Life Sci Date: 2017-08-08 Impact factor: 9.261

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Authors: Karina P Abrahao; Armando G Salinas; David M Lovinger
Journal: Neuron Date: 2017-12-20 Impact factor: 17.173

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Authors: Wenting Li; Wanhong Zuo; Wei Wu; Qi Kang Zuo; Rao Fu; Liangzhi Wu; Haifeng Zhang; Michael Ndukwe; Jiang-Hong Ye
Journal: Neuropharmacology Date: 2019-06-27 Impact factor: 5.250