Literature DB >> 2837209

Evidence of autocrine regulation in human hepatoma cell lines.

T F Tsai1, Y K Yauk, C K Chou, L P Ting, C Chang, C P Hu, S H Han, T S Su.   

Abstract

Human hepatoma cell lines were studied for the expression of platelet-derived growth factor (PDGF), insulin-like growth factor-I (IGF-I) and their receptors at the mRNA level. Transcripts of PDGF were consistently detected in these cell lines. In addition, some cell lines also expressed PDGF receptor RNA. Moreover, RNA of IGF-I and its receptor were detected in every cell line examined. These results suggest that autocrine regulation may be an important mechanism for the maintenance of the transformed state of human hepatoma cells.

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Year:  1988        PMID： 2837209     DOI： 10.1016/s0006-291x(88)81186-0

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  13 in total

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Authors:  W C Su; S C Shiesh; H S Liu; C Y Chen; N H Chow; X Z Lin
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4.  Insulin-like growth factor-1 mRNA isoforms and insulin-like growth factor-1 receptor mRNA expression in chronic hepatitis C.

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Review 5.  The IGF axis and hepatocarcinogenesis.

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6.  Insulin-like growth factor I expression by tumors of neuroectodermal origin with the t(11;22) chromosomal translocation. A potential autocrine growth factor.

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7.  Enhanced expression of the protein kinase substrate p36 in human hepatocellular carcinoma.

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Review 8.  Growth factor receptors and related signalling pathways as targets for novel treatment strategies of hepatocellular cancer.

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Review 9.  Biological effects of growth hormone on carbohydrate and lipid metabolism.

Authors:  Archana Vijayakumar; Ruslan Novosyadlyy; Yingjie Wu; Shoshana Yakar; Derek LeRoith
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10.  Potentiating the efficacy of molecular targeted therapy for hepatocellular carcinoma by inhibiting the insulin-like growth factor pathway.

Authors:  Da-Liang Ou; Bin-Shyun Lee; Ya-Chi Chang; Liang-In Lin; Jun-Yang Liou; Chiun Hsu; Ann-Lii Cheng
Journal:  PLoS One       Date:  2013-06-20       Impact factor: 3.240
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