Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Recent progress in autophagic lysosome reformation.

Literature DB >> 28371052

Recent progress in autophagic lysosome reformation.

Abstract

Autophagic lysosome reformation (ALR) is the terminal step of autophagy and is essential for maintaining lysosome homeostasis during autophagy. During ALR, tubules are extruded from autolysosomes, and small vesicles named proto-lysosomes, which are composed of lysosomal membrane components, are generated from these tubules. Eventually, proto-lysosomes mature into functional lysosomes. In this review, we will summarize recent progress in understanding the regulation, mechanisms and physiological functions of ALR.

Keywords: KIF5B; autophagic lysosome reformation (ALR); autophagy; clathrin; in vitro reconstitution; membrane deformation; phospholipid

Mesh：

Substances：

Year: 2017 PMID： 28371052 DOI： 10.1111/tra.12484

Source DB: PubMed Journal: Traffic ISSN： 1398-9219 Impact factor: 6.215

Keyword Cloud
Cited

32 in total

Review 1. Biological Functions of Autophagy Genes: A Disease Perspective.

Authors: Beth Levine; Guido Kroemer
Journal: Cell Date: 2019-01-10 Impact factor: 41.582

2. Axl inhibitor R428 induces apoptosis of cancer cells by blocking lysosomal acidification and recycling independent of Axl inhibition.

Authors: Fangfang Chen; Qiaoling Song; Qiang Yu
Journal: Am J Cancer Res Date: 2018-08-01 Impact factor: 6.166

Recent progress in autophagic lysosome reformation.

Review 1. Biological Functions of Autophagy Genes: A Disease Perspective.

2. Axl inhibitor R428 induces apoptosis of cancer cells by blocking lysosomal acidification and recycling independent of Axl inhibition.

3. Rab6 promotes insulin receptor and cathepsin trafficking to regulate autophagy induction and activity in Drosophila.

Review 4. The lysosome as an imperative regulator of autophagy and cell death.

Review 5. Golgi requires a new casting in the screenplay of mucopolysaccharidosis II cytopathology.

Review 6. Lysosome: The metabolic signaling hub.

Review 7. Phosphoinositide 3-kinase pathways and autophagy require phosphatidylinositol phosphate kinases.

8. BLOC1S1/GCN5L1/BORCS1 is a critical mediator for the initiation of autolysosomal tubulation.

Review 9. Proteostatic imbalance and protein spreading in amyotrophic lateral sclerosis.

10. DCZ5248, a novel dual inhibitor of Hsp90 and autophagy, exerts antitumor activity against colon cancer.