Monitoring Reactions on Solid Phases with Raman Spectroscopy.

The benefits of Raman spectroscopy were shown for the on-bead monitoring of diverse reactions. Raman spectroscopy was used for the development of new procedures on established linker systems, the real-time observation of several reactions on solid phases and the estimation of the reaction time for a new cleavage strategy. Selected conversions on solid phases, such as the on-bead conversion of functional groups and the attachment of novel building blocks, were demonstrated. Raman spectra were obtained after isolation and purification of the solid supports, but they were also measured directly in the reaction vessels. Even the detection of Raman-active functional groups in swollen polymer resins and in reaction mixtures was demonstrated, and allows real-time observation of the progress of diverse reactions on solid supports.