Diana J Moreno1, Sebastián Pino, Ángela Ríos, Francisco Lopera, Henry Ostos, Marc Via, Gabriel Bedoya. 1. *Molecular Genetics Group ‡Neuroscience Group, University of Antioquia, Medellín †Neuropsychology Group, Surcolombiana University §Genomic Medicine Group, Surcolombiana University, Neiva, Colombia ∥Department of Clinical Psychology and Psychobiology and Institute of Neuroscience, Barcelona University ¶Research Institute Sant Joan de Déu (IR-SJD), Barcelona, Spain.
Abstract
INTRODUCTION: Differences in the prevalence of dementia among populations and in the effect of apolipoprotein E (APOE) on the emergence of Alzheimer disease (AD), which is the main type of dementia, have been reported. METHODS: This study estimated the ancestry of a group of individuals with late-onset Alzheimer disease (LOAD) (N=280) and established whether there were any differences when compared with a control group (N=357) in a sample of the Colombian population. RESULTS: When the analyses were adjusted for known risk factors such as age, sex, presence of APOE[Latin Small Letter Open E]4, socioeconomic status, educational attainment, and place of birth, African ancestry was associated with an increased LOAD risk (odds ratio: 1.55; 95% confidence interval, 1.09-2.03; P=0.029), whereas Native American ancestry was associated with lower risk (odds ratio: 0.75; 95% confidence interval, 0.61-0.98; P=0.046), for every 10% increase in ancestry. In addition, there were significant differences in the proportion of Native American ancestry between carriers and noncarriers of the APOE[Latin Small Letter Open E]4 allele (Mann-Whitney U test, P=0.047), with noncarriers having higher mean Native American ancestry when compared with carriers. CONCLUSIONS: Our results are consistent with the presence of variants of African origin in the genome of the Colombian population and different from APOE[Latin Small Letter Open E]4 that represents a risk factor for the development of LOAD, whereas variants of Native American origin may be conferring protection. However, unknown environmental factors or epigenetic differences among continental groups could also explain the observed associations.
INTRODUCTION: Differences in the prevalence of dementia among populations and in the effect of apolipoprotein E (APOE) on the emergence of Alzheimer disease (AD), which is the main type of dementia, have been reported. METHODS: This study estimated the ancestry of a group of individuals with late-onset Alzheimer disease (LOAD) (N=280) and established whether there were any differences when compared with a control group (N=357) in a sample of the Colombian population. RESULTS: When the analyses were adjusted for known risk factors such as age, sex, presence of APOE[Latin Small Letter Open E]4, socioeconomic status, educational attainment, and place of birth, African ancestry was associated with an increased LOAD risk (odds ratio: 1.55; 95% confidence interval, 1.09-2.03; P=0.029), whereas Native American ancestry was associated with lower risk (odds ratio: 0.75; 95% confidence interval, 0.61-0.98; P=0.046), for every 10% increase in ancestry. In addition, there were significant differences in the proportion of Native American ancestry between carriers and noncarriers of the APOE[Latin Small Letter Open E]4 allele (Mann-Whitney U test, P=0.047), with noncarriers having higher mean Native American ancestry when compared with carriers. CONCLUSIONS: Our results are consistent with the presence of variants of African origin in the genome of the Colombian population and different from APOE[Latin Small Letter Open E]4 that represents a risk factor for the development of LOAD, whereas variants of Native American origin may be conferring protection. However, unknown environmental factors or epigenetic differences among continental groups could also explain the observed associations.
Authors: Elizabeth E Blue; Andréa R V R Horimoto; Shubhabrata Mukherjee; Ellen M Wijsman; Timothy A Thornton Journal: Alzheimers Dement Date: 2019-10-09 Impact factor: 21.566
Authors: Mario Alfredo Parra; Sandra Baez; Lucas Sedeño; Cecilia Gonzalez Campo; Hernando Santamaría-García; Ivan Aprahamian; Paulo Hf Bertolucci; Julian Bustin; Maria Aparecida Camargos Bicalho; Carlos Cano-Gutierrez; Paulo Caramelli; Marcia L F Chaves; Patricia Cogram; Bárbara Costa Beber; Felipe A Court; Leonardo Cruz de Souza; Nilton Custodio; Andres Damian; Myriam de la Cruz; Roberta Diehl Rodriguez; Sonia Maria Dozzi Brucki; Lais Fajersztajn; Gonzalo A Farías; Fernanda G De Felice; Raffaele Ferrari; Fabricio Ferreira de Oliveira; Sergio T Ferreira; Ceres Ferretti; Marcio Luiz Figueredo Balthazar; Norberto Anizio Ferreira Frota; Patricio Fuentes; Adolfo M García; Patricia J Garcia; Fábio Henrique de Gobbi Porto; Lissette Duque Peñailillo; Henry Willy Engler; Irene Maier; Ignacio F Mata; Christian Gonzalez-Billault; Oscar L Lopez; Laura Morelli; Ricardo Nitrini; Yakeel T Quiroz; Alejandra Guerrero Barragan; David Huepe; Fabricio Joao Pio; Claudia Kimie Suemoto; Renata Kochhann; Silvia Kochen; Fiona Kumfor; Serggio Lanata; Bruce Miller; Leticia Lessa Mansur; Mirna Lie Hosogi; Patricia Lillo; Jorge Llibre Guerra; David Lira; Francisco Lopera; Adelina Comas; José Alberto Avila-Funes; Ana Luisa Sosa; Claudia Ramos; Elisa de Paula França Resende; Heather M Snyder; Ioannis Tarnanas; Jenifer Yokoyama; Juan Llibre; Juan Felipe Cardona; Kate Possin; Kenneth S Kosik; Rosa Montesinos; Sebastian Moguilner; Patricia Cristina Lourdes Solis; Renata Eloah de Lucena Ferretti-Rebustini; Jeronimo Martin Ramirez; Diana Matallana; Lingani Mbakile-Mahlanza; Alyne Mendonça Marques Ton; Ronnielly Melo Tavares; Eliane C Miotto; Graciela Muniz-Terrera; Luis Arnoldo Muñoz-Nevárez; David Orozco; Maira Okada de Oliveira; Olivier Piguet; Maritza Pintado Caipa; Stefanie Danielle Piña Escudero; Lucas Porcello Schilling; André Luiz Rodrigues Palmeira; Mônica Sanches Yassuda; Jose Manuel Santacruz-Escudero; Rodrigo Bernardo Serafim; Jerusa Smid; Andrea Slachevsky; Cecilia Serrano; Marcio Soto-Añari; Leonel Tadao Takada; Lea Tenenholz Grinberg; Antonio Lucio Teixeira; Maira Tonidandel Barbosa; Dominic Trépel; Agustin Ibanez Journal: Alzheimers Dement Date: 2020-11-20 Impact factor: 21.566