| Literature DB >> 28368576 |
Carlos Caro1,2, María Luisa García-Martín1,3, Manuel Pernia Leal1,2.
Abstract
pH-responsive nanogels (NGs) were used to prepare high-efficiency magnetic resonance imaging dual T1/T2 contrast agents for pH imaging. The polymeric NG matrix acts as a strong polydentate ligand that chelates the Mn cations in its inner cavity generating a hybrid NG structure. The Mn chelate NG is sensitive to pH changes, such that protonation induces a change of the polymer hydration state and consequent swelling. The swollen nanogel allows water molecules to enter and interact with the Mn chelate, shortening the relaxation time (switch ON) and giving rise to positive or negative contrast on T1- or T2-weighted magnetic resonance images.Entities:
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Year: 2017 PMID： 28368576 DOI： 10.1021/acs.biomac.7b00224
Source DB: PubMed Journal: Biomacromolecules ISSN： 1525-7797 Impact factor: 6.988