Justin S Smith1, Breton Line2, Shay Bess3, Christopher I Shaffrey1, Han Jo Kim4, Gregory Mundis5, Justin K Scheer6, Eric Klineberg7, Michael O'Brien8, Richard Hostin8, Munish Gupta9, Alan Daniels10, Michael Kelly9, Jeffrey L Gum11, Frank J Schwab4, Virginie Lafage4, Renaud Lafage4, Tamir Ailon12, Peter Passias3, Themistocles Protopsaltis3, Todd J Albert4, K Daniel Riew13, Robert Hart14, Doug Burton15, Vedat Deviren16, Christopher P Ames17, International Spine Study Group. 1. Department of Neurosurgery, University of Virginia, Charlottesville, Virginia. 2. International Spine Study Group Foundation, Brighton, Colorado. 3. Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, New York, New York. 4. Department of Orthopaedic Surgery, Hospital for Special Surgery, New York City, New York. 5. San Diego Center for Spinal Disorders, La Jolla, California. 6. University of California San Diego, School of Medicine, San Diego, California. 7. Department of Orthopaedic Surgery, University of California, Davis, Sacramento, California. 8. Department of Orthopaedic Surgery, Baylor Scoliosis Center, Plano, Texas. 9. Department of Orthopaedic Surgery, Washington University, St Louis, Missouri. 10. Department of Orthopaedic Surgery, Brown University, Providence, Rhode Island. 11. Department of Orthopaedic Surgery, Leatherman Spine Center, Louisville, Kentucky. 12. Departments of Neurosurgery and Orthopaedic Surgery, University of British Columbia, Vancouver, British Columbia, Canada. 13. Department of Orthopedic Surgery, Columbia University, New York. 14. Department of Orthopaedic Surgery, Oregon Health and Science University, Portland, Oregon. 15. Department of Orthopaedic Surgery, University of Kansas Medical Center, Kansas City, Kansas. 16. Department of Orthopedic Surgery, University of California, San Francisco, San Francisco, California. 17. Department of Neurological Surgery, University of California, San Francisco, San Francisco, California.
Abstract
BACKGROUND: Although adult cervical spine deformity (ACSD) is associated with pain and disability, its health impact has not been quantified in comparison to other chronic diseases. OBJECTIVE: To perform a comparative analysis of the health impact of symptomatic ACSD to US normative and chronic disease values using EQ-5D (EuroQuol-5 Dimensions questionnaire) scores. METHODS: ACSD patients presenting for surgical treatment were identified from a prospectively collected multicenter database. Baseline demographics and EQ-5D scores were collected and compared with US normative and disease state values. RESULTS: Of 121 ACSD patients, 115 (95%) completed the EQ-5D (60% women, mean age 61 years, previous spine surgery in 44%). Diagnoses included kyphosis with mid-cervical (63.4%), cervico-thoracic (23.5%), or thoracic (8.7%) apex and primary coronal deformity (4.3%). The mean ACSD EQ-5D index was 0.511 (standard definition = 0.224), which is 34% below the bottom 25th percentile (0.780) for similar age- and gender-matched US normative populations. Mean ACSD EQ-5D index values were worse than the bottom 25th percentile for several other disease states, including chronic ischemic heart disease (0.708), malignant breast cancer (0.708), and malignant prostate cancer (0.708). ACSD mean index values were comparable to the bottom 25th percentile values for blindness/low vision (0.543), emphysema (0.508), renal failure (0.506), and stroke (0.463). EQ-5D scores did not significantly differ based on cervical deformity type ( P = .66). CONCLUSION: The health impact of symptomatic ACSD is substantial, with negative impact across all EQ-5D domains. The mean ACSD EQ-5D index was comparable to the bottom 25th percentile values for blindness/low vision, emphysema, renal failure, and stroke.
BACKGROUND: Although adult cervical spine deformity (ACSD) is associated with pain and disability, its health impact has not been quantified in comparison to other chronic diseases. OBJECTIVE: To perform a comparative analysis of the health impact of symptomatic ACSD to US normative and chronic disease values using EQ-5D (EuroQuol-5 Dimensions questionnaire) scores. METHODS: ACSD patients presenting for surgical treatment were identified from a prospectively collected multicenter database. Baseline demographics and EQ-5D scores were collected and compared with US normative and disease state values. RESULTS: Of 121 ACSD patients, 115 (95%) completed the EQ-5D (60% women, mean age 61 years, previous spine surgery in 44%). Diagnoses included kyphosis with mid-cervical (63.4%), cervico-thoracic (23.5%), or thoracic (8.7%) apex and primary coronal deformity (4.3%). The mean ACSD EQ-5D index was 0.511 (standard definition = 0.224), which is 34% below the bottom 25th percentile (0.780) for similar age- and gender-matched US normative populations. Mean ACSD EQ-5D index values were worse than the bottom 25th percentile for several other disease states, including chronic ischemic heart disease (0.708), malignant breast cancer (0.708), and malignant prostate cancer (0.708). ACSD mean index values were comparable to the bottom 25th percentile values for blindness/low vision (0.543), emphysema (0.508), renal failure (0.506), and stroke (0.463). EQ-5D scores did not significantly differ based on cervical deformity type ( P = .66). CONCLUSION: The health impact of symptomatic ACSD is substantial, with negative impact across all EQ-5D domains. The mean ACSD EQ-5D index was comparable to the bottom 25th percentile values for blindness/low vision, emphysema, renal failure, and stroke.
Authors: Bassel G Diebo; Neil V Shah; Maximillian Solow; Vincent Challier; Carl B Paulino; Peter G Passias; Renaud Lafage; Frank J Schwab; Han Jo Kim; Virginie Lafage Journal: Orthopade Date: 2018-06 Impact factor: 1.087
Authors: Scott L Zuckerman; Anton Gillespie; Mena G Kerolus; Ian A Buchanan; Alex S Ha; Meghan Cerpa; Eric Leung; K Daniel Riew; Lawrence G Lenke; Ronald A Lehman Journal: J Spine Surg Date: 2021-09
Authors: Cole Bortz; Peter G Passias; Katherine Elizabeth Pierce; Haddy Alas; Avery Brown; Sara Naessig; Waleed Ahmad; Renaud Lafage; Christopher P Ames; Bassel G Diebo; Breton G Line; Eric O Klineberg; Douglas C Burton; Robert K Eastlack; Han Jo Kim; Daniel M Sciubba; Alex Soroceanu; Shay Bess; Christopher I Shaffrey; Frank J Schwab; Justin S Smith; Virginie Lafage Journal: J Craniovertebr Junction Spine Date: 2020-06-05
Authors: Peter G Passias; Samantha R Horn; Tina Raman; Avery E Brown; Virginie Lafage; Renaud Lafage; Justin S Smith; Cole A Bortz; Frank A Segreto; Katherine E Pierce; Haddy Alas; Breton G Line; Bassel G Diebo; Alan H Daniels; Han Jo Kim; Alex Soroceanu; Gregory M Mundis; Themistocles S Protopsaltis; Eric O Klineberg; Douglas C Burton; Robert A Hart; Frank J Schwab; Shay Bess; Christopher I Shaffrey; Christopher P Ames Journal: J Craniovertebr Junction Spine Date: 2019 Jul-Sep
Authors: Katherine E Pierce; Peter Gust Passias; Avery E Brown; Cole A Bortz; Haddy Alas; Renaud Lafage; Oscar Krol; Dean Chou; Douglas C Burton; Breton Line; Eric Klineberg; Robert Hart; Jeffrey Gum; Alan Daniels; Kojo Hamilton; Shay Bess; Themistocles Protopsaltis; Christopher Shaffrey; Frank A Schwab; Justin S Smith; Virginie Lafage; Christopher Ames Journal: J Craniovertebr Junction Spine Date: 2021-09-08
Authors: Han Jo Kim; Yu-Cheng Yao; Christopher I Shaffrey; Justin S Smith; Michael P Kelly; Munish Gupta; Todd J Albert; Themistocles S Protopsaltis; Gregory M Mundis; Peter Passias; Eric Klineberg; Shay Bess; Virginie Lafage; Christopher P Ames Journal: Global Spine J Date: 2020-11-23
Authors: Andrew J Schoenfeld; Caleb M Yeung; Daniel G Tobert; Lananh Nguyen; Peter G Passias; John H Shin; James D Kang; Marco L Ferrone Journal: Spine (Phila Pa 1976) Date: 2022-01-15 Impact factor: 3.241