Literature DB >> 28368290

Maturing of the nuclear receptor family.

Mitchell A Lazar.   

Abstract

Members of the nuclear receptor (NR) superfamily of ligand-regulated transcription factors play important roles in reproduction, development, and physiology. In humans, genetic mutations in NRs are causes of rare diseases, while hormones and drugs that target NRs are in widespread therapeutic use. The present issue of the JCI includes a series of Review articles focused on specific NRs and their wide range of biological functions. Here I reflect on the past, present, and potential future highlights of research on the NR superfamily.

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Year:  2017        PMID： 28368290      PMCID： PMC5373857          DOI： 10.1172/JCI92949

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  30 in total

Review 1.  How many drug targets are there?

Authors:  John P Overington; Bissan Al-Lazikani; Andrew L Hopkins
Journal:  Nat Rev Drug Discov       Date:  2006-12       Impact factor: 84.694

2.  Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA.

Authors:  B F Luisi; W X Xu; Z Otwinowski; L P Freedman; K R Yamamoto; P B Sigler
Journal:  Nature       Date:  1991-08-08       Impact factor: 49.962

3.  Unique ERalpha cistromes control cell type-specific gene regulation.

Authors:  Susan A Krum; Gustavo A Miranda-Carboni; Mathieu Lupien; Jerome Eeckhoute; Jason S Carroll; Myles Brown
Journal:  Mol Endocrinol       Date:  2008-09-25

4.  Altered gene expression during differentiation: population changes in hybridizable RNA after stimulation of the chick oviduct with oestrogen.

Authors:  B W O'Malley; W L McGuire; P A Middleton
Journal:  Nature       Date:  1968-06-29       Impact factor: 49.962

5.  The c-erb-A protein is a high-affinity receptor for thyroid hormone.

Authors:  J Sap; A Muñoz; K Damm; Y Goldberg; J Ghysdael; A Leutz; H Beug; B Vennström
Journal:  Nature       Date:  1986 Dec 18-31       Impact factor: 49.962

6.  Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor.

Authors:  J W Lee; H S Choi; J Gyuris; R Brent; D D Moore
Journal:  Mol Endocrinol       Date:  1995-02

7.  Immunochemical analysis of the glucocorticoid receptor: identification of a third domain separate from the steroid-binding and DNA-binding domains.

Authors:  J Carlstedt-Duke; S Okret; O Wrange; J A Gustafsson
Journal:  Proc Natl Acad Sci U S A       Date:  1982-07       Impact factor: 11.205

8.  The function and structure of the metal coordination sites within the glucocorticoid receptor DNA binding domain.

Authors:  L P Freedman; B F Luisi; Z R Korszun; R Basavappa; P B Sigler; K R Yamamoto
Journal:  Nature       Date:  1988-08-11       Impact factor: 49.962

9.  Sequence and characterization of a coactivator for the steroid hormone receptor superfamily.

Authors:  S A Oñate; S Y Tsai; M J Tsai; B W O'Malley
Journal:  Science       Date:  1995-11-24       Impact factor: 47.728

10.  The N-terminal DNA-binding 'zinc finger' of the oestrogen and glucocorticoid receptors determines target gene specificity.

Authors:  S Green; V Kumar; I Theulaz; W Wahli; P Chambon
Journal:  EMBO J       Date:  1988-10       Impact factor: 11.598
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  24 in total

1.  Regulation of calcific vascular and valvular disease by nuclear receptors.

Authors:  Tamer Sallam; Yin Tintut; Linda L Demer
Journal:  Curr Opin Lipidol       Date:  2019-10       Impact factor: 4.776

2.  TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

Authors:  Karen Dendoncker; Steven Timmermans; Jolien Vandewalle; Melanie Eggermont; Joanna Lempiäinen; Ville Paakinaho; Evelien Van Hamme; Sylviane Dewaele; Sofie Vandevyver; Marlies Ballegeer; Jolien Souffriau; Lise Van Wyngene; Kelly Van Looveren; Tineke Vanderhaeghen; Rudi Beyaert; Karolien De Bosscher; Jorma J Palvimo; Marc Van Montagu; Claude Libert
Journal:  Proc Natl Acad Sci U S A       Date:  2019-06-10       Impact factor: 11.205

Review 3.  Genomic insights into MeCP2 function: A role for the maintenance of chromatin architecture.

Authors:  Daniel R Connolly; Zhaolan Zhou
Journal:  Curr Opin Neurobiol       Date:  2019-08-17       Impact factor: 6.627

4.  Obesity alters pathology and treatment response in inflammatory disease.

Authors:  Caroline Whitty; Cody T Mowery; Yuqiong Liang; Sagar P Bapat; Arum Yoo; Zewen Jiang; Michael C Peters; Ling-Juan Zhang; Ian Vogel; Carmen Zhou; Vinh Q Nguyen; Zhongmei Li; Christina Chang; Wandi S Zhu; Annette T Hastie; Helen He; Xin Ren; Wenli Qiu; Sarah G Gayer; Chang Liu; Eun Jung Choi; Marlys Fassett; Jarish N Cohen; Jamie L Sturgill; Laura E Crotty Alexander; Jae Myoung Suh; Christopher Liddle; Annette R Atkins; Ruth T Yu; Michael Downes; Sihao Liu; Barbara S Nikolajczyk; In-Kyu Lee; Emma Guttman-Yassky; K Mark Ansel; Prescott G Woodruff; John V Fahy; Dean Sheppard; Richard L Gallo; Chun Jimmie Ye; Ronald M Evans; Ye Zheng; Alexander Marson
Journal:  Nature       Date:  2022-03-30       Impact factor: 69.504

5.  Reversing the curse on PPARγ.

Authors:  Mitchell A Lazar
Journal:  J Clin Invest       Date:  2018-05-14       Impact factor: 14.808

Review 6.  Chromatin reprogramming in breast cancer.

Authors:  Erin E Swinstead; Ville Paakinaho; Gordon L Hager
Journal:  Endocr Relat Cancer       Date:  2018-04-24       Impact factor: 5.678

Review 7.  Deciphering Steroid Receptor Crosstalk in Hormone-Driven Cancers.

Authors:  Thu H Truong; Carol A Lange
Journal:  Endocrinology       Date:  2018-12-01       Impact factor: 4.736

8.  The nuclear receptor RORα protects against angiotensin II-induced cardiac hypertrophy and heart failure.

Authors:  Ju Youn Beak; Hong Soon Kang; Wei Huang; Page H Myers; Dawn E Bowles; Anton M Jetten; Brian C Jensen
Journal:  Am J Physiol Heart Circ Physiol       Date:  2018-11-02       Impact factor: 4.733

9.  CAR directs T cell adaptation to bile acids in the small intestine.

Authors:  Mei Lan Chen; Xiangsheng Huang; Hongtao Wang; Courtney Hegner; Yujin Liu; Jinsai Shang; Amber Eliason; Huitian Diao; HaJeung Park; Blake Frey; Guohui Wang; Sarah A Mosure; Laura A Solt; Douglas J Kojetin; Alex Rodriguez-Palacios; Deborah A Schady; Casey T Weaver; Matthew E Pipkin; David D Moore; Mark S Sundrud
Journal:  Nature       Date:  2021-04-07       Impact factor: 69.504

10.  An intrinsically disordered region-mediated confinement state contributes to the dynamics and function of transcription factors.

Authors:  David A Garcia; Thomas A Johnson; Diego M Presman; Gregory Fettweis; Kaustubh Wagh; Lorenzo Rinaldi; Diana A Stavreva; Ville Paakinaho; Rikke A M Jensen; Susanne Mandrup; Arpita Upadhyaya; Gordon L Hager
Journal:  Mol Cell       Date:  2021-02-08       Impact factor: 19.328
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