Literature DB >> 2836678

Evidence for a non-opioid sigma binding site in the guinea-pig myenteric plexus.

F Roman1, X Pascaud, D Vauché, J L Junien.   

Abstract

The presence of a binding site to (+)-(3H)SKF 10,047 was demonstrated in a guinea-pig myenteric plexus (MYP) membrane preparation. Specific binding to this receptor was saturable, reversible, linear with protein concentration and consisted of two components, a high affinity site (KD = 46 +/- 5 nM; Bmax = 3.4 +/- 0.5 pmole/g wet weight) and a low affinity site (KD= = 342 +/- 72 nM; Bmax = 22 +/- 3 pmole/g wet weight). Morphine and naloxone 10(-4) M were unable to displace (+)-(3H)SKF 10,047 binding. Haloperidol, imipramine, ethylketocyclazocine and propranolol were among the most potent compounds to inhibit this specific binding. These results suggest the presence of a non-opioid haloperidol sensitive sigma receptor in the MYP of the guinea-pig.

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Year:  1988        PMID： 2836678     DOI： 10.1016/0024-3205(88)90373-6

Source DB:  PubMed          Journal:  Life Sci        ISSN： 0024-3205            Impact factor:   5.037


  8 in total

1.  Sigma receptors [σRs]: biology in normal and diseased states.

Authors:  Colin G Rousseaux; Stephanie F Greene
Journal:  J Recept Signal Transduct Res       Date:  2015-06-09       Impact factor: 2.092

2.  Effects of sigma ligands on the cloned mu-, delta- and kappa-opioid receptors co-expressed with G-protein-activated K+ (GIRK) channel in Xenopus oocytes.

Authors:  T Kobayashi; K Ikeda; T Ichikawa; S Togashi; T Kumanishi
Journal:  Br J Pharmacol       Date:  1996-09       Impact factor: 8.739

3.  A sigma ligand, SR 31747A, potently modulates Staphylococcal enterotoxin B-induced cytokine production in mice.

Authors:  B Bourrié; J M Benoît; J M Derocq; M Esclangon; C Thomas; G Le Fur; P Casellas
Journal:  Immunology       Date:  1996-07       Impact factor: 7.397

4.  The sigma ligand, igmesine, inhibits cholera toxin and Escherichia coli enterotoxin induced jejunal secretion in the rat.

Authors:  J L Turvill; P Kasapidis; M J Farthing
Journal:  Gut       Date:  1999-10       Impact factor: 23.059

5.  Antidiarrhoeal properties of a novel sigma ligand (JO 2871) on toxigenic diarrhoea in mice: mechanisms of action.

Authors:  V Theodorou; M Chovet; H Eutamene; H Fargeau; M Dassaud; M Toulouse; C Bihoreau; F J Roman; L Bueno
Journal:  Gut       Date:  2002-10       Impact factor: 23.059

6.  Biologically active MK-801 and SKF-10,047 binding sites distinct from those in rat brain are expressed on human lung cancer cells.

Authors:  R Maneckjee; J D Minna
Journal:  Mol Biol Cell       Date:  1992-06       Impact factor: 4.138

7.  Biphasic effects of sigma ligands on the neuronal response to N-methyl-D-aspartate.

Authors:  R Bergeron; C de Montigny; G Debonnel
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-03       Impact factor: 3.000

8.  Lessons on the Sigma-1 Receptor in TNBS-Induced Rat Colitis: Modulation of the UCHL-1, IL-6 Pathway.

Authors:  Nikoletta Almási; Szilvia Török; Szabolcs Dvorácskó; Csaba Tömböly; Ákos Csonka; Zoltán Baráth; Zsolt Murlasits; Zsuzsanna Valkusz; Anikó Pósa; Csaba Varga; Krisztina Kupai
Journal:  Int J Mol Sci       Date:  2020-06-05       Impact factor: 5.923
  8 in total

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