Yasuharu Tabara1, Hidenori Arai2, Yuhko Hirao3, Yoshimitsu Takahashi4, Kazuya Setoh5, Takahisa Kawaguchi5, Shinji Kosugi6, Yasuki Ito3, Takeo Nakayama4, Fumihiko Matsuda5. 1. Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan. Electronic address: tabara@genome.med.kyoto-u.ac.jp. 2. National Center for Geriatrics and Gerontology, Obu, Japan. 3. Research and Development Center, Denka Seiken Co., Ltd., Tokyo, Japan. 4. Department of Health Informatics, Kyoto University School of Public Health, Kyoto, Japan. 5. Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan. 6. Department of Medical Ethics and Medical Genetics, Kyoto University School of Public Health, Kyoto, Japan.
Abstract
AIMS: In addition to its antiatherogenic action, high-density lipoprotein (HDL) may also have an antidiabetes function. Although the biological actions of small HDL (HDL3) and large HDL (HDL2) subclasses may be different, evidence in support of that hypothesis is lacking. The aim of this study was to clarify the difference in prognostic significance of HDL subclasses for exacerbation of insulin resistance and incidence of type 2 diabetes in the general population. METHODS: Study participants included 8365 community residents 52±13years of age not taking lipid lowering drugs. Serum HDL cholesterol subclasses and low-density lipoprotein subclasses, were measured by a homogeneous assay. Insulin resistance was assessed by homeostasis model assessment of insulin resistance (HOMA-IR). RESULTS: Cross-sectional analysis adjusted for possible covariates found that HDL2 cholesterol (HDL2-C) levels were inversely associated with HOMA-IR (β=-0.169, p<0.001), whereas HDL3-C had the opposite association (β=0.054, p<0.001). Similar results were found in an analysis for type 2 diabetes (HDL2-C, odds ratio=0.96, p=0.001; HDL3-C, odds ratio=1.04, p=0.181). In a longitudinal analysis with 5.0years of follow-up, HDL2-C was inversely associated with exacerbation of insulin resistance (β=-0.163, p<0.001); HDL3-C had the opposite association (β=0.026, p=0.037). During follow-up, 205 individuals were newly diagnosed with diabetes, and HDL2-C level was associated with an inverse risk of type 2 diabetes incidence (odds ratio=0.98, p=0.006). CONCLUSIONS: HDL may have an antidiabetic function; the prognostic value of HDL2-C for diabetes and insulin resistance might be better than that of HDL3-C.
AIMS: In addition to its antiatherogenic action, high-density lipoprotein (HDL) may also have an antidiabetes function. Although the biological actions of small HDL (HDL3) and large HDL (HDL2) subclasses may be different, evidence in support of that hypothesis is lacking. The aim of this study was to clarify the difference in prognostic significance of HDL subclasses for exacerbation of insulin resistance and incidence of type 2 diabetes in the general population. METHODS: Study participants included 8365 community residents 52±13years of age not taking lipid lowering drugs. Serum HDLcholesterol subclasses and low-density lipoprotein subclasses, were measured by a homogeneous assay. Insulin resistance was assessed by homeostasis model assessment of insulin resistance (HOMA-IR). RESULTS: Cross-sectional analysis adjusted for possible covariates found that HDL2cholesterol (HDL2-C) levels were inversely associated with HOMA-IR (β=-0.169, p<0.001), whereas HDL3-C had the opposite association (β=0.054, p<0.001). Similar results were found in an analysis for type 2 diabetes (HDL2-C, odds ratio=0.96, p=0.001; HDL3-C, odds ratio=1.04, p=0.181). In a longitudinal analysis with 5.0years of follow-up, HDL2-C was inversely associated with exacerbation of insulin resistance (β=-0.163, p<0.001); HDL3-C had the opposite association (β=0.026, p=0.037). During follow-up, 205 individuals were newly diagnosed with diabetes, and HDL2-C level was associated with an inverse risk of type 2 diabetes incidence (odds ratio=0.98, p=0.006). CONCLUSIONS:HDL may have an antidiabetic function; the prognostic value of HDL2-C for diabetes and insulin resistance might be better than that of HDL3-C.
Authors: Dina Khedr; Mona Hafez; Jairo Lumpuy-Castillo; Soha Emam; Antoine Abdel-Massih; Fatma Elmougy; Rasha Elkaffas; Ignacio Mahillo-Fernández; Oscar Lorenzo; Noha Musa Journal: Int J Mol Sci Date: 2020-07-18 Impact factor: 5.923
Authors: Sara Sokooti; Jose L Flores-Guerrero; Lyanne M Kieneker; Hiddo J L Heerspink; Margery A Connelly; Stephan J L Bakker; Robin P F Dullaart Journal: J Clin Endocrinol Metab Date: 2021-05-13 Impact factor: 5.958
Authors: Sara Sokooti; Tamas Szili-Torok; Jose L Flores-Guerrero; Maryse C J Osté; António W Gomes-Neto; Jenny E Kootstra-Ros; Hiddo J L Heerspink; Margery A Connelly; Stephan J L Bakker; Robin P F Dullaart Journal: Biomolecules Date: 2020-03-21