Xiuying Li1, Jinfan Sun2, Shuenqin Hu3. 1. Medical Faculty, Kunming University of Science and Technology, 650093, Kunming, Yunnan, China. lixying98@163.com. 2. LaoBoYunTang Medicine Co., Ltd, Chuxiong, China. 3. Department of Gynecology and Obstetrics, the First Affiliated Hospital of Kunming Medical University, Kunming, China.
Abstract
BACKGROUND: It has been shown that caveolin-1 plays a potential role as a diagnostic and prognostic biomarker in various cancer types. The aim of the present study was to clarify whether caveolin-1 expressed in the breast cancer stroma could be a prognostic factor for breast cancer patients. METHODS: We searched the PubMed, ScienceDirect and Web of Science databases for published literature investigating associations between stromal caveolin-1 expression and survival outcome in breast cancer patients. With respect to survival outcomes, the pooled hazard ratios (HRs) of caveolin-1 and the 95% confidence intervals (CI) were calculated. RESULTS: Our meta-analysis identified a total of 10 studies involving 2072 cases. Further investigation demonstrated that a lack of caveolin-1 expression in the breast cancer stroma is a hazard for overall survival (OS) (HR = 2.33, 95% CI: 1.57-3.46) and disease-free/progression-free survival (DFS/PFS) (HR = 3.05, 95% CI: 2.26-4.12) in breast cancer patients. Moreover, lack of caveolin-1 expression in the cancer-associated fibroblasts was a significant predictor of DFS/PFS (HR = 2.79, 95% CI: 1.75-4.46). CONCLUSION: Our results indicated that lack of expression of caveolin-1 in the breast cancer stroma is associated with a poor prognosis.
BACKGROUND: It has been shown that caveolin-1 plays a potential role as a diagnostic and prognostic biomarker in various cancer types. The aim of the present study was to clarify whether caveolin-1 expressed in the breast cancer stroma could be a prognostic factor for breast cancerpatients. METHODS: We searched the PubMed, ScienceDirect and Web of Science databases for published literature investigating associations between stromal caveolin-1 expression and survival outcome in breast cancerpatients. With respect to survival outcomes, the pooled hazard ratios (HRs) of caveolin-1 and the 95% confidence intervals (CI) were calculated. RESULTS: Our meta-analysis identified a total of 10 studies involving 2072 cases. Further investigation demonstrated that a lack of caveolin-1 expression in the breast cancer stroma is a hazard for overall survival (OS) (HR = 2.33, 95% CI: 1.57-3.46) and disease-free/progression-free survival (DFS/PFS) (HR = 3.05, 95% CI: 2.26-4.12) in breast cancerpatients. Moreover, lack of caveolin-1 expression in the cancer-associated fibroblasts was a significant predictor of DFS/PFS (HR = 2.79, 95% CI: 1.75-4.46). CONCLUSION: Our results indicated that lack of expression of caveolin-1 in the breast cancer stroma is associated with a poor prognosis.
Entities:
Keywords:
Breast cancer; Cancer-associated fibroblasts; Caveolin-1; Meta-analysis; Tumor stroma
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