| Literature DB >> 28363771 |
Yanping Liu1, Xuwu Zhang2, Zhiwei Liu2, Longgang Wang2, Liyao Luo2, Meili Wang3, Qianqian Wang2, Dawei Gao4.
Abstract
A novel synthesis approach is first developed to fabricate a multifunctional smart nanodrug delivery system: gold nanoshell-coated betulinic acid liposomes (AuNS-BA-Lips) mediated by a glutathione. The AuNS-BA-Lips exhibited good size distribution (149.4±2.4nm), preferable photothermal conversion ability and synergistic chemo-photothermal therapy. Additionally, the absorption wavelength of AuNS-BA-Lips showed a significantly red-shifted to near infrared (NIR) region, which can strongly absorbed NIR laser and efficiently convert it into localized heat, thus providing controlled drug release and antitumor thermotherapy. Moreover, the nanocarriers excited by NIR light significantly promoted cell uptake compared to those without irradiation, resulting in an enhanced intracellular drug accumulation. Upon NIR irradiation, the AuNS-BA-Lips showed highly efficient antitumor effects on tumor-bearing mice with an inhibition rate of 83.02%, thus demonstrating a remarkable synergistic therapeutic effect of chemotherapy and thermotherapy. Therefore, this work provides new insight into developing a multifunctional antitumor drug.Entities:
Keywords: Antitumor; Betulinic acid; Controlled release; Gold nanoshell liposome; Photothermal therapy
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Year: 2017 PMID： 28363771 DOI： 10.1016/j.nano.2017.03.012
Source DB: PubMed Journal: Nanomedicine ISSN： 1549-9634 Impact factor: 5.307